Source: hRBCD ; ID: IPI00180305
Marked as 'Integral membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)

Gene names: UBR4 , KIAA0462, KIAA1307, RBAF600, ZUBR1
Protein names and data: UBR4_HUMAN , E3 ubiquitin-protein ligase UBR4; 6.3.2.- , 600 kDa retinoblastoma protein-associated factor; N-recognin-4; Retinoblastoma-associated factor of 600 kDa; RBAF600; p600; Zinc finger UBR1-type protein 1 Lenght: 5183 a.a.
Mass: 573841 Da
fasta formatted sequence

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Genetic variants

Database cross-references

UniProt: Q5T4S7
Ensembl: ENST00000375217
Ensembl: ENST00000375218
Ensembl: ENST00000375226
Ensembl: ENST00000375254
Ensembl: ENST00000375267
MIM: 609890
neXtProt: NX_Q5T4S7
Antibodypedia: Q5T4S7 (may not find the protein thus also not any antibody)
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