UBXN1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UBXN1 , SAKS1
Protein names and data: UBXN1_HUMAN , UBX domain-containing protein 1 , SAPK substrate protein 1; UBA/UBX 33.3 kDa protein Lenght: 297 a.a.
Mass: 33325 Da
fasta formatted sequence
Function: Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.
Cellular location: Cytoplasm (By similarity).

Genetic variants

Database cross-references

UniProt: Q04323
Ensembl: ENST00000294119
Ensembl: ENST00000301935
neXtProt: NX_Q04323
Antibodypedia: Q04323 (may not find the protein thus also not any antibody)
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