UCHL3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UCHL3
Protein names and data: UCHL3_HUMAN , Ubiquitin carboxyl-terminal hydrolase isozyme L3; UCH-L3; 3.4.19.12 , Ubiquitin thioesterase L3 Lenght: 230 a.a.
Mass: 26183 Da
fasta formatted sequence
Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin- signaling and insulin-induced adipogenesis. Required for stress- response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm.
Tissue specificity: Highly expressed in heart, skeletal muscle, and testis.

Database cross-references

UniProt: P15374
Ensembl: ENST00000377595
MIM: 603090
neXtProt: NX_P15374
Antibodypedia: P15374 (may not find the protein thus also not any antibody)
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