UCHL5_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)

Gene names: UCHL5 , UCH37 , AD-019, CGI-70
Protein names and data: UCHL5_HUMAN , Ubiquitin carboxyl-terminal hydrolase isozyme L5; UCH-L5; 3.4.19.12 , Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5 Lenght: 329 a.a.
Mass: 37607 Da
fasta formatted sequence

Function: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.

Genetic variants

Database cross-references

UniProt: Q9Y5K5
Ensembl: ENST00000367448
Ensembl: ENST00000367449
Ensembl: ENST00000367454
Ensembl: ENST00000367455
MIM: 610667
neXtProt: NX_Q9Y5K5
Antibodypedia: Q9Y5K5 (may not find the protein thus also not any antibody)
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