UFD1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UFD1L
Protein names and data: UFD1_HUMAN , Ubiquitin fusion degradation protein 1 homolog; UB fusion protein 1 Lenght: 307 a.a.
Mass: 34500 Da
fasta formatted sequence
Function: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Pathway: Protein degradation; proteasomal ubiquitin-dependent pathway.
Cellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity).
Tissue specificity: Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.

Genetic variants

Database cross-references

UniProt: Q92890
Ensembl: ENST00000263202
Ensembl: ENST00000399523
MIM: 601754
neXtProt: NX_Q92890
Antibodypedia: Q92890 (may not find the protein thus also not any antibody)
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