UIMC1_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: UIMC1 , RAP80, RXRIP110
Protein names and data: UIMC1_HUMAN , BRCA1-A complex subunit RAP80 , Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1 Lenght: 719 a.a.
Mass: 79727 Da
fasta formatted sequence
Function: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Cellular location: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue specificity: Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.

Genetic variants

Database cross-references

UniProt: Q96RL1
Ensembl: ENST00000377227
Ensembl: ENST00000506128
Ensembl: ENST00000511320
MIM: 609433
neXtProt: NX_Q96RL1
Antibodypedia: Q96RL1 (may not find the protein thus also not any antibody)
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