ULA1_HUMAN

Source: hRBCD ; ID: IPI00018968
PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: NAE1 , APPBP1 , HPP1
Protein names and data: ULA1_HUMAN , NEDD8-activating enzyme E1 regulatory subunit , Amyloid beta precursor protein-binding protein 1, 59 kDa; APP-BP1; Amyloid protein-binding protein 1; Proto-oncogene protein 1 Lenght: 534 a.a.
Mass: 60246 Da
fasta formatted sequence
Function: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Pathway: Protein modification; protein neddylation.
Cellular location: Cell membrane. Note=Colocalizes with APP in lipid rafts.
Tissue specificity: Ubiquitous in fetal tissues. Expressed throughout the adult brain.

Genetic variants

Database cross-references

UniProt: Q13564
Ensembl: ENST00000290810
Ensembl: ENST00000379463
MIM: 603385
neXtProt: NX_Q13564
Antibodypedia: Q13564 (may not find the protein thus also not any antibody)
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