ULK3_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ULK3
Protein names and data: ULK3_HUMAN , Serine/threonine-protein kinase ULK3; 2.7.11.1 , Unc-51-like kinase 3 Lenght: 472 a.a.
Mass: 53444 Da
fasta formatted sequence
Function: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cellular location: Cytoplasm. Note=Localizes to pre- autophagosomal structure during cellular senescence.
Tissue specificity: Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optic nerve. In the central nervous system, lowest levels in the spinal cord.

Genetic variants

Database cross-references

UniProt: Q6PHR2
Ensembl: ENST00000440863
Ensembl: ENST00000569437
MIM: 613472
neXtProt: NX_Q6PHR2
Antibodypedia: Q6PHR2 (may not find the protein thus also not any antibody)
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