URM1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: URM1 , C9orf74
Protein names and data: URM1_HUMAN , Ubiquitin-related modifier 1 Lenght: 101 a.a.
Mass: 11380 Da
fasta formatted sequence
Function: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as an ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Pathway: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis.
Cellular location: Cytoplasm.

Database cross-references

UniProt: Q9BTM9
Ensembl: ENST00000372853
Ensembl: ENST00000452446
MIM: 612693
neXtProt: NX_Q9BTM9
Antibodypedia: Q9BTM9 (may not find the protein thus also not any antibody)
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