URP2_HUMAN

Source: hRBCD ; ID: IPI00216699
PM19886704
BSc_CH
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: FERMT3 , KIND3, MIG2B, URP2
Protein names and data: URP2_HUMAN , Fermitin family homolog 3 , Kindlin-3; MIG2-like protein; Unc-112-related protein 2 Lenght: 667 a.a.
Mass: 75953 Da
fasta formatted sequence
Function: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Disease:
Cellular location: Cell projection, podosome (By similarity). Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells (By similarity).
Tissue specificity: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

Database cross-references

UniProt: Q86UX7
Ensembl: ENST00000279227
Ensembl: ENST00000345728
MIM: 607901
MIM: 612840
neXtProt: NX_Q86UX7
Antibodypedia: Q86UX7 (may not find the protein thus also not any antibody)
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