USP9X_HUMAN

Source: hRBCD ; ID: IPI00003964
PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: USP9X , DFFRX, FAM, USP9
Protein names and data: USP9X_HUMAN , Probable ubiquitin carboxyl-terminal hydrolase FAF-X; 3.4.19.12 , Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X Lenght: 2570 a.a.
Mass: 292280 Da
fasta formatted sequence
Function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Cytoplasm.
Tissue specificity: Widely expressed in embryonic and adult tissues.

Database cross-references

UniProt: Q93008
Ensembl: ENST00000324545
Ensembl: ENST00000378308
MIM: 300072
neXtProt: NX_Q93008
Antibodypedia: Q93008 (may not find the protein thus also not any antibody)
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