VAC14_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VAC14 , TAX1BP2, TRX
Protein names and data: VAC14_HUMAN , Protein VAC14 homolog , Tax1-binding protein 2 Lenght: 782 a.a.
Mass: 87973 Da
fasta formatted sequence
Function: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Cellular location: Endosome membrane. Microsome membrane (By similarity). Note=Mainly associated with membranes of the late endocytic pathway.
Tissue specificity: Ubiquitously expressed.

Database cross-references

UniProt: Q08AM6
Ensembl: ENST00000261776
MIM: 604632
neXtProt: NX_Q08AM6
Antibodypedia: Q08AM6 (may not find the protein thus also not any antibody)
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