Source: PM23856902
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: VAMP8
Protein names and data: VAMP8_HUMAN , Vesicle-associated membrane protein 8; VAMP-8 , Endobrevin; EDB Lenght: 100 a.a.
Mass: 11438 Da
fasta formatted sequence

Function: SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also required for dense-granule secretion in platelets. Plays also a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes.
Cellular location: Lysosome membrane; Single-pass type IV membrane protein (Probable). Late endosome membrane; Single-pass type IV membrane protein (Probable). Note=Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi. Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell. Cycles through the apical but not through the basolateral plasma membrane. Apical region of acinar cells; in zymogen granule membranes (By similarity).
Tissue specificity: Platelets.

Database cross-references

UniProt: Q9BV40
Ensembl: ENST00000263864
MIM: 603177
neXtProt: NX_Q9BV40
Antibodypedia: Q9BV40 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.