Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)

Gene names: VCAM1 , L1CAM
Protein names and data: VCAM1_HUMAN , Vascular cell adhesion protein 1; V-CAM 1; VCAM-1 , INCAM-100; CD106; Flags: Precursor Lenght: 739 a.a.
Mass: 81276 Da
fasta formatted sequence

Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Cellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Genetic variants

Database cross-references

UniProt: P19320
Ensembl: ENST00000294728
Ensembl: ENST00000347652
Ensembl: ENST00000370119
MIM: 192225
neXtProt: NX_P19320
Antibodypedia: P19320 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.