RBCC Red Blood Cell Collection

VCAM1_HUMAN

Source: BD_CD
Marked as 'Integral membrane protein'
Confidence: high (a blood group or CD marker) Search PubMed for
(RBC AND this entry)
Gene names: VCAM1 , L1CAM
Protein names and data: VCAM1_HUMAN , Vascular cell adhesion protein 1; V-CAM 1; VCAM-1 , INCAM-100; CD106; Flags: Precursor Lenght: 739 a.a.
Mass: 81276 Da
fasta formatted sequence
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Cellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.

Genetic variants

18 - 18 M -> I (in dbSNP:rs34228330). VAR_049951 34228330
318 - 318 S -> F (in dbSNP:rs3783611). VAR_014309 3783611
384 - 384 T -> A (in dbSNP:rs3783612). VAR_014310 3783612
413 - 413 G -> A (in dbSNP:rs3783613). VAR_014311 3783613
421 - 421 V -> I (in dbSNP:rs34100871). VAR_049952 34100871
488 - 488 H -> R (in dbSNP:rs34199378). VAR_049953 34199378
716 - 716 I -> L (in dbSNP:rs3783615). VAR_014312 3783615

Database cross-references

UniProt: P19320
Ensembl: ENST00000294728
Ensembl: ENST00000347652
Ensembl: ENST00000370119
MIM: 192225
neXtProt: NX_P19320
Antibodypedia: P19320 (may not find the protein thus also not any antibody)
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