VCIP1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VCPIP1 , KIAA1850, VCIP135
Protein names and data: VCIP1_HUMAN , Deubiquitinating protein VCIP135; 3.4.19.12 , Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein Lenght: 1222 a.a.
Mass: 134321 Da
fasta formatted sequence
Function: Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.
Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Cellular location: Endoplasmic reticulum (By similarity). Golgi apparatus, Golgi stack (By similarity). Note=Associated with Golgi stacks and endoplasmic reticulum (By similarity).

Database cross-references

UniProt: Q96JH7
Ensembl: ENST00000310421
MIM: 611745
neXtProt: NX_Q96JH7
Antibodypedia: Q96JH7 (may not find the protein thus also not any antibody)
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