Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: VDAC1 , VDAC
Protein names and data: VDAC1_HUMAN , Voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1 , Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM Lenght: 283 a.a.
Mass: 30773 Da
fasta formatted sequence

Function: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
Cellular location: Mitochondrion outer membrane. Cell membrane.
Tissue specificity: Heart, liver and skeletal muscle.

Database cross-references

UniProt: P21796
Ensembl: ENST00000265333
Ensembl: ENST00000395044
Ensembl: ENST00000395047
MIM: 604492
neXtProt: NX_P21796
Antibodypedia: P21796 (may not find the protein thus also not any antibody)
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