VPS29_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VPS29 , DC15, DC7, MDS007
Protein names and data: VPS29_HUMAN , Vacuolar protein sorting-associated protein 29; hVPS29; 3.1.3.3 , PEP11 homolog; Vesicle protein sorting 29 Lenght: 182 a.a.
Mass: 20506 Da
fasta formatted sequence
Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).
Catalytic activity: O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate.
Cellular location: Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein (By similarity).
Tissue specificity: Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.

Database cross-references

UniProt: Q9UBQ0
Ensembl: ENST00000360579
Ensembl: ENST00000549578
MIM: 606932
neXtProt: NX_Q9UBQ0
Antibodypedia: Q9UBQ0 (may not find the protein thus also not any antibody)
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