VPS36_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VPS36 , C13orf9, EAP45 , CGI-145
Protein names and data: VPS36_HUMAN , Vacuolar protein-sorting-associated protein 36 , ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36 Lenght: 386 a.a.
Mass: 43817 Da
fasta formatted sequence
Function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Cellular location: Cytoplasm. Endosome. Late endosome. Membrane. Nucleus (Probable). Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.

Database cross-references

UniProt: Q86VN1
Ensembl: ENST00000378060
MIM: 610903
neXtProt: NX_Q86VN1
Antibodypedia: Q86VN1 (may not find the protein thus also not any antibody)
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