VPS4B_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VPS4B , SKD1, VPS42 , MIG1
Protein names and data: VPS4B_HUMAN , Vacuolar protein sorting-associated protein 4B; 3.6.4.6 , Cell migration-inducing gene 1 protein; Suppressor of K(+) transport growth defect 1; Protein SKD1 Lenght: 444 a.a.
Mass: 49302 Da
fasta formatted sequence
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
Catalytic activity: ATP + H(2)O = ADP + phosphate.
Cellular location: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.
Tissue specificity: Ubiquitously expressed.

Genetic variants

Database cross-references

UniProt: O75351
Ensembl: ENST00000238497
MIM: 609983
neXtProt: NX_O75351
Antibodypedia: O75351 (may not find the protein thus also not any antibody)
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