VRK1_HUMAN

Source: hRBCD ; ID: IPI00019640
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: VRK1
Protein names and data: VRK1_HUMAN , Serine/threonine-protein kinase VRK1; 2.7.11.1 , Vaccinia-related kinase 1 Lenght: 396 a.a.
Mass: 45476 Da
fasta formatted sequence
Function: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Disease:
Cellular location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle (By similarity). Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue specificity: Widely expressed. Highly expressed in fetal liver, testis and thymus.

Database cross-references

UniProt: Q99986
Ensembl: ENST00000216639
MIM: 602168
MIM: 607596
neXtProt: NX_Q99986
Antibodypedia: Q99986 (may not find the protein thus also not any antibody)
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