VTA1_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VTA1 , C6orf55 , HSPC228, My012
Protein names and data: VTA1_HUMAN , Vacuolar protein sorting-associated protein VTA1 homolog , Dopamine-responsive gene 1 protein; DRG-1; LYST-interacting protein 5; LIP5; SKD1-binding protein 1; SBP1 Lenght: 307 a.a.
Mass: 33879 Da
fasta formatted sequence
Function: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Cellular location: Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable).

Genetic variants

Database cross-references

UniProt: Q9NP79
Ensembl: ENST00000367630
MIM: 610902
neXtProt: NX_Q9NP79
Antibodypedia: Q9NP79 (may not find the protein thus also not any antibody)
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