WIBG_HUMAN

Source: PM19886704
PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: WIBG , PYM
Protein names and data: WIBG_HUMAN , Partner of Y14 and mago , Protein wibg homolog Lenght: 204 a.a.
Mass: 22656 Da
fasta formatted sequence
Function: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post- transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
Cellular location: Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Shuttles between the nucleus and the cytoplasm. Nuclear export is mediated by XPO1/CRM1.

Genetic variants

Database cross-references

UniProt: Q9BRP8
Ensembl: ENST00000398213
Ensembl: ENST00000408946
neXtProt: NX_Q9BRP8
Antibodypedia: Q9BRP8 (may not find the protein thus also not any antibody)
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