XPO2_HUMAN

Source: hRBCD ; ID: IPI00022744
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: CSE1L , CAS, XPO2
Protein names and data: XPO2_HUMAN , Exportin-2; Exp2 , Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter Lenght: 971 a.a.
Mass: 110417 Da
fasta formatted sequence
Function: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Tissue specificity: Highly expressed in proliferating cells.

Genetic variants

Database cross-references

UniProt: P55060
Ensembl: ENST00000262982
Ensembl: ENST00000396192
MIM: 601342
neXtProt: NX_P55060
Antibodypedia: P55060 (may not find the protein thus also not any antibody)
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