XPO4_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: XPO4 , KIAA1721
Protein names and data: XPO4_HUMAN , Exportin-4; Exp4 Lenght: 1151 a.a.
Mass: 130139 Da
fasta formatted sequence
Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Cellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Genetic variants

Database cross-references

UniProt: Q9C0E2
Ensembl: ENST00000255305
MIM: 611449
neXtProt: NX_Q9C0E2
Antibodypedia: Q9C0E2 (may not find the protein thus also not any antibody)
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