ZCCHV_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ZC3HAV1 , ZC3HDC2 , PRO1677
Protein names and data: ZCCHV_HUMAN , Zinc finger CCCH-type antiviral protein 1 , ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP Lenght: 902 a.a.
Mass: 101431 Da
fasta formatted sequence
Function: Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)- specific ribonuclease PARN to remove the poly(A) tail, and the 3'- 5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Cellular location: Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner (By similarity). Isoform 2: Cytoplasm.

Genetic variants

Database cross-references

UniProt: Q7Z2W4
Ensembl: ENST00000242351
Ensembl: ENST00000471652
MIM: 607312
neXtProt: NX_Q7Z2W4
Antibodypedia: Q7Z2W4 (may not find the protein thus also not any antibody)
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