ZN363_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: RCHY1 , ARNIP, CHIMP, PIRH2, RNF199, ZNF363
Protein names and data: ZN363_HUMAN , RING finger and CHY zinc finger domain-containing protein 1; 6.3.2.- , Androgen receptor N-terminal-interacting protein; CH-rich-interacting match with PLAG1; E3 ubiquitin-protein ligase Pirh2; RING finger protein 199; Zinc finger protein 363; p53-induced RING-H2 protein; hPirh2 Lenght: 261 a.a.
Mass: 30110 Da
fasta formatted sequence
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
Pathway: Protein modification; protein ubiquitination.
Cellular location: Nucleus. Nucleus speckle. Cytoplasm.

Database cross-references

UniProt: Q96PM5
Ensembl: ENST00000324439
Ensembl: ENST00000505105
Ensembl: ENST00000513257
MIM: 607680
neXtProt: NX_Q96PM5
Antibodypedia: Q96PM5 (may not find the protein thus also not any antibody)
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