Full text data of ACTR3B
ACTR3B
(ARP11, ARP4)
[Confidence: low (only semi-automatic identification from reviews)]
Actin-related protein 3B (ARP3-beta; Actin-like protein 3B; Actin-related protein ARP4)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Actin-related protein 3B (ARP3-beta; Actin-like protein 3B; Actin-related protein ARP4)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q9P1U1
ID ARP3B_HUMAN Reviewed; 418 AA.
AC Q9P1U1; A8MTG1; B4DFW4; Q7Z526; Q96BT2;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=Actin-related protein 3B;
DE AltName: Full=ARP3-beta;
DE AltName: Full=Actin-like protein 3B;
DE AltName: Full=Actin-related protein ARP4;
GN Name=ACTR3B; Synonyms=ARP11, ARP4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10806390; DOI=10.1046/j.1432-1327.2000.01306.x;
RA Jay P., Berge-Lefranc J.-L., Massacrier A., Roessler E., Wallis D.,
RA Muenke M., Gastaldi M., Taviaux S., Cau P., Berta P.;
RT "ARP3beta, the gene encoding a new human actin-related protein, is
RT alternatively spliced and predominantly expressed in brain neuronal
RT cells.";
RL Eur. J. Biochem. 267:2921-2928(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Ding J.B., Yu L., Zhang M., Dai F.Y., Jiang J.X., Zhao S.Y.;
RT "Cloning of a novel human cDNA homology to human actin-related protein
RT Arp3(ARP3) mRNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Peripheral blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059;
RA Shindo-Okada N., Shimizu K.;
RT "Isolation of a novel actin-related gene expressed in low-metastatic
RT PC-14 human lung adenocarcinoma.";
RL Biochem. Biophys. Res. Commun. 280:61-67(2001).
RN [7]
RP FUNCTION.
RX PubMed=14651955; DOI=10.1016/j.bbrc.2003.10.200;
RA Shindo-Okada N., Iigo M.;
RT "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14
RT human lung adenocarcinoma cells.";
RL Biochem. Biophys. Res. Commun. 312:889-896(2003).
CC -!- FUNCTION: Plays a role in the organization of the actin
CC cytoskeleton. May function as ATP-binding component of the Arp2/3
CC complex which is involved in regulation of actin polymerization
CC and together with an activating nucleation-promoting factor (NPF)
CC mediates the formation of branched actin networks. May decrease
CC the metastatic potential of tumors.
CC -!- SUBUNIT: Interacts with the Arp2/3 complex composed of ARP2, ARP3,
CC ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-
CC ARC and ARPC5/p16-ARC.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
CC Cell projection (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9P1U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P1U1-2; Sequence=VSP_034418;
CC Name=3;
CC IsoId=Q9P1U1-3; Sequence=VSP_041474;
CC -!- TISSUE SPECIFICITY: Detected in fetal brain. Detected throughout
CC the adult brain, in neurons from gray matter, but not in white
CC matter. Detected in liver, skeletal muscle and pancreas. Detected
CC in lung adenocarcinoma cells with low metastatic potential, but
CC not in lung adenocarcinoma cells with high metastatic potential.
CC -!- SIMILARITY: Belongs to the actin family. ARP3 subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97150.1; Type=Frameshift; Positions=Several;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF023453; AAC98904.1; -; mRNA.
DR EMBL; AF086920; AAP97150.1; ALT_SEQ; mRNA.
DR EMBL; AK294292; BAG57575.1; -; mRNA.
DR EMBL; AK315534; BAG37914.1; -; mRNA.
DR EMBL; AC072057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015207; AAH15207.1; -; mRNA.
DR EMBL; BC008682; AAH08682.1; -; mRNA.
DR RefSeq; NP_001035225.1; NM_001040135.2.
DR RefSeq; NP_065178.1; NM_020445.5.
DR UniGene; Hs.647117; -.
DR ProteinModelPortal; Q9P1U1; -.
DR SMR; Q9P1U1; 3-417.
DR IntAct; Q9P1U1; 3.
DR MINT; MINT-1397170; -.
DR STRING; 9606.ENSP00000256001; -.
DR PhosphoSite; Q9P1U1; -.
DR DMDM; 74753111; -.
DR PaxDb; Q9P1U1; -.
DR PRIDE; Q9P1U1; -.
DR DNASU; 57180; -.
DR Ensembl; ENST00000256001; ENSP00000256001; ENSG00000133627.
DR Ensembl; ENST00000377776; ENSP00000367007; ENSG00000133627.
DR Ensembl; ENST00000397282; ENSP00000380452; ENSG00000133627.
DR Ensembl; ENST00000537264; ENSP00000446157; ENSG00000133627.
DR GeneID; 57180; -.
DR KEGG; hsa:57180; -.
DR UCSC; uc003wle.2; human.
DR CTD; 57180; -.
DR GeneCards; GC07P152456; -.
DR HGNC; HGNC:17256; ACTR3B.
DR neXtProt; NX_Q9P1U1; -.
DR PharmGKB; PA142672645; -.
DR eggNOG; COG5277; -.
DR HOGENOM; HOG000233339; -.
DR HOVERGEN; HBG003771; -.
DR InParanoid; Q9P1U1; -.
DR OMA; GDPRKWI; -.
DR OrthoDB; EOG7TMZRM; -.
DR PhylomeDB; Q9P1U1; -.
DR SignaLink; Q9P1U1; -.
DR GeneWiki; ACTR3B; -.
DR GenomeRNAi; 57180; -.
DR NextBio; 63219; -.
DR PRO; PR:Q9P1U1; -.
DR ArrayExpress; Q9P1U1; -.
DR Bgee; Q9P1U1; -.
DR CleanEx; HS_ACTR3B; -.
DR Genevestigator; Q9P1U1; -.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin-related.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Actin-binding; Alternative splicing; ATP-binding;
KW Cell projection; Complete proteome; Cytoplasm; Cytoskeleton;
KW Nucleotide-binding; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 418 Actin-related protein 3B.
FT /FTId=PRO_0000342358.
FT MOD_RES 2 2 N-acetylalanine (By similarity).
FT MOD_RES 240 240 N6-acetyllysine (By similarity).
FT MOD_RES 244 244 N6-acetyllysine (By similarity).
FT MOD_RES 251 251 N6-acetyllysine (By similarity).
FT MOD_RES 254 254 N6-acetyllysine (By similarity).
FT VAR_SEQ 1 88 Missing (in isoform 2).
FT /FTId=VSP_034418.
FT VAR_SEQ 318 387 Missing (in isoform 3).
FT /FTId=VSP_041474.
FT VARIANT 250 250 R -> Q (in dbSNP:rs2260545).
FT /FTId=VAR_048188.
SQ SEQUENCE 418 AA; 47608 MW; BC1040ED5D3B832F CRC64;
MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR VLRGVDDLDF
FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY LRAEPEDHYF LMTEPPLNTP
ENREYLAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV
AEGYVIGSCI KHIPIAGRDI TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK
EFAKYDVDPR KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV
DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS EELSGGRIKP
KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY EEYGPSICRH NPVFGVMS
//
ID ARP3B_HUMAN Reviewed; 418 AA.
AC Q9P1U1; A8MTG1; B4DFW4; Q7Z526; Q96BT2;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-OCT-2000, sequence version 1.
DT 22-JAN-2014, entry version 104.
DE RecName: Full=Actin-related protein 3B;
DE AltName: Full=ARP3-beta;
DE AltName: Full=Actin-like protein 3B;
DE AltName: Full=Actin-related protein ARP4;
GN Name=ACTR3B; Synonyms=ARP11, ARP4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, AND
RP TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10806390; DOI=10.1046/j.1432-1327.2000.01306.x;
RA Jay P., Berge-Lefranc J.-L., Massacrier A., Roessler E., Wallis D.,
RA Muenke M., Gastaldi M., Taviaux S., Cau P., Berta P.;
RT "ARP3beta, the gene encoding a new human actin-related protein, is
RT alternatively spliced and predominantly expressed in brain neuronal
RT cells.";
RL Eur. J. Biochem. 267:2921-2928(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Ding J.B., Yu L., Zhang M., Dai F.Y., Jiang J.X., Zhao S.Y.;
RT "Cloning of a novel human cDNA homology to human actin-related protein
RT Arp3(ARP3) mRNA.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala, and Peripheral blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA Waterston R.H., Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Colon, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=11162478; DOI=10.1006/bbrc.2000.4059;
RA Shindo-Okada N., Shimizu K.;
RT "Isolation of a novel actin-related gene expressed in low-metastatic
RT PC-14 human lung adenocarcinoma.";
RL Biochem. Biophys. Res. Commun. 280:61-67(2001).
RN [7]
RP FUNCTION.
RX PubMed=14651955; DOI=10.1016/j.bbrc.2003.10.200;
RA Shindo-Okada N., Iigo M.;
RT "Expression of the Arp11 gene suppresses the tumorigenicity of PC-14
RT human lung adenocarcinoma cells.";
RL Biochem. Biophys. Res. Commun. 312:889-896(2003).
CC -!- FUNCTION: Plays a role in the organization of the actin
CC cytoskeleton. May function as ATP-binding component of the Arp2/3
CC complex which is involved in regulation of actin polymerization
CC and together with an activating nucleation-promoting factor (NPF)
CC mediates the formation of branched actin networks. May decrease
CC the metastatic potential of tumors.
CC -!- SUBUNIT: Interacts with the Arp2/3 complex composed of ARP2, ARP3,
CC ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-
CC ARC and ARPC5/p16-ARC.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
CC Cell projection (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9P1U1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P1U1-2; Sequence=VSP_034418;
CC Name=3;
CC IsoId=Q9P1U1-3; Sequence=VSP_041474;
CC -!- TISSUE SPECIFICITY: Detected in fetal brain. Detected throughout
CC the adult brain, in neurons from gray matter, but not in white
CC matter. Detected in liver, skeletal muscle and pancreas. Detected
CC in lung adenocarcinoma cells with low metastatic potential, but
CC not in lung adenocarcinoma cells with high metastatic potential.
CC -!- SIMILARITY: Belongs to the actin family. ARP3 subfamily.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97150.1; Type=Frameshift; Positions=Several;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AF023453; AAC98904.1; -; mRNA.
DR EMBL; AF086920; AAP97150.1; ALT_SEQ; mRNA.
DR EMBL; AK294292; BAG57575.1; -; mRNA.
DR EMBL; AK315534; BAG37914.1; -; mRNA.
DR EMBL; AC072057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015207; AAH15207.1; -; mRNA.
DR EMBL; BC008682; AAH08682.1; -; mRNA.
DR RefSeq; NP_001035225.1; NM_001040135.2.
DR RefSeq; NP_065178.1; NM_020445.5.
DR UniGene; Hs.647117; -.
DR ProteinModelPortal; Q9P1U1; -.
DR SMR; Q9P1U1; 3-417.
DR IntAct; Q9P1U1; 3.
DR MINT; MINT-1397170; -.
DR STRING; 9606.ENSP00000256001; -.
DR PhosphoSite; Q9P1U1; -.
DR DMDM; 74753111; -.
DR PaxDb; Q9P1U1; -.
DR PRIDE; Q9P1U1; -.
DR DNASU; 57180; -.
DR Ensembl; ENST00000256001; ENSP00000256001; ENSG00000133627.
DR Ensembl; ENST00000377776; ENSP00000367007; ENSG00000133627.
DR Ensembl; ENST00000397282; ENSP00000380452; ENSG00000133627.
DR Ensembl; ENST00000537264; ENSP00000446157; ENSG00000133627.
DR GeneID; 57180; -.
DR KEGG; hsa:57180; -.
DR UCSC; uc003wle.2; human.
DR CTD; 57180; -.
DR GeneCards; GC07P152456; -.
DR HGNC; HGNC:17256; ACTR3B.
DR neXtProt; NX_Q9P1U1; -.
DR PharmGKB; PA142672645; -.
DR eggNOG; COG5277; -.
DR HOGENOM; HOG000233339; -.
DR HOVERGEN; HBG003771; -.
DR InParanoid; Q9P1U1; -.
DR OMA; GDPRKWI; -.
DR OrthoDB; EOG7TMZRM; -.
DR PhylomeDB; Q9P1U1; -.
DR SignaLink; Q9P1U1; -.
DR GeneWiki; ACTR3B; -.
DR GenomeRNAi; 57180; -.
DR NextBio; 63219; -.
DR PRO; PR:Q9P1U1; -.
DR ArrayExpress; Q9P1U1; -.
DR Bgee; Q9P1U1; -.
DR CleanEx; HS_ACTR3B; -.
DR Genevestigator; Q9P1U1; -.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR InterPro; IPR004000; Actin-related.
DR InterPro; IPR020902; Actin/actin-like_CS.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Actin-binding; Alternative splicing; ATP-binding;
KW Cell projection; Complete proteome; Cytoplasm; Cytoskeleton;
KW Nucleotide-binding; Polymorphism; Reference proteome.
FT INIT_MET 1 1 Removed (By similarity).
FT CHAIN 2 418 Actin-related protein 3B.
FT /FTId=PRO_0000342358.
FT MOD_RES 2 2 N-acetylalanine (By similarity).
FT MOD_RES 240 240 N6-acetyllysine (By similarity).
FT MOD_RES 244 244 N6-acetyllysine (By similarity).
FT MOD_RES 251 251 N6-acetyllysine (By similarity).
FT MOD_RES 254 254 N6-acetyllysine (By similarity).
FT VAR_SEQ 1 88 Missing (in isoform 2).
FT /FTId=VSP_034418.
FT VAR_SEQ 318 387 Missing (in isoform 3).
FT /FTId=VSP_041474.
FT VARIANT 250 250 R -> Q (in dbSNP:rs2260545).
FT /FTId=VAR_048188.
SQ SEQUENCE 418 AA; 47608 MW; BC1040ED5D3B832F CRC64;
MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR VLRGVDDLDF
FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY LRAEPEDHYF LMTEPPLNTP
ENREYLAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV
AEGYVIGSCI KHIPIAGRDI TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK
EFAKYDVDPR KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV
DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS EELSGGRIKP
KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY EEYGPSICRH NPVFGVMS
//