Full text data of SLC2A3
SLC2A3
(GLUT3)
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain; GLUT-3)
Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain; GLUT-3)
hRBCD
IPI00003909
IPI00003909 Solute carrier family 2, facilitated glucose transporter, member 3 Solute carrier family 2, facilitated glucose transporter, member 3 membrane n/a n/a 2 1 2 n/a n/a n/a n/a n/a 1 2 n/a n/a n/a 1 n/a n/a 2 2 integral membrane protein LWGTQDVSQDIQEMK, QVTVLELFRVS, AFEGQAHGADR found at its expected molecular weight found at molecular weight
IPI00003909 Solute carrier family 2, facilitated glucose transporter, member 3 Solute carrier family 2, facilitated glucose transporter, member 3 membrane n/a n/a 2 1 2 n/a n/a n/a n/a n/a 1 2 n/a n/a n/a 1 n/a n/a 2 2 integral membrane protein LWGTQDVSQDIQEMK, QVTVLELFRVS, AFEGQAHGADR found at its expected molecular weight found at molecular weight
UniProt
P11169
ID GTR3_HUMAN Reviewed; 496 AA.
AC P11169; B2R606; D3DUU6; Q6I9U2; Q9UG15;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUL-1989, sequence version 1.
DT 22-JAN-2014, entry version 146.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 3;
DE AltName: Full=Glucose transporter type 3, brain;
DE Short=GLUT-3;
GN Name=SLC2A3; Synonyms=GLUT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal skeletal muscle;
RX PubMed=3170580;
RA Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B.,
RA Bell G.I.;
RT "Evidence for a family of human glucose transporter-like proteins.
RT Sequence and gene localization of a protein expressed in fetal
RT skeletal muscle and other tissues.";
RL J. Biol. Chem. 263:15245-15248(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Stuart C.A., Wen K.G., Acosta M., Wood T.G.;
RT "Resistance and expression of glucose transporters in human skeletal
RT muscle.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 302-453.
RC TISSUE=Articular cartilage;
RA Neama G., Richardson S., Bell S., Carter S., Mobasheri A.;
RT "Molecular characterization and cloning of glucose transporters in
RT human articular chondrocytes.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP SUBSTRATE SPECIFICITY SITE.
RX PubMed=9477959; DOI=10.1021/bi972322u;
RA Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W.;
RT "QLS motif in transmembrane helix VII of the glucose transporter
RT family interacts with the C-1 (position) of D-glucose and is involved
RT in substrate selection at the exofacial binding site.";
RL Biochemistry 37:1322-1326(1998).
CC -!- FUNCTION: Facilitative glucose transporter. Probably a neuronal
CC glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain. Expressed in many
CC tissues.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M20681; AAB61083.1; -; mRNA.
DR EMBL; AF274892; AAF82116.1; -; Genomic_DNA.
DR EMBL; AF274889; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; AF274890; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; AF274891; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; CR457413; CAG33694.1; -; mRNA.
DR EMBL; AK312386; BAG35303.1; -; mRNA.
DR EMBL; CH471116; EAW88644.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88645.1; -; Genomic_DNA.
DR EMBL; BC039196; AAH39196.1; -; mRNA.
DR EMBL; AY034634; AAK56796.1; -; mRNA.
DR PIR; A31986; A31986.
DR PIR; T14798; T14798.
DR RefSeq; NP_008862.1; NM_006931.2.
DR UniGene; Hs.419240; -.
DR ProteinModelPortal; P11169; -.
DR SMR; P11169; 9-466.
DR IntAct; P11169; 4.
DR MINT; MINT-4999361; -.
DR STRING; 9606.ENSP00000075120; -.
DR ChEMBL; CHEMBL5215; -.
DR GuidetoPHARMACOLOGY; 877; -.
DR TCDB; 2.A.1.1.91; the major facilitator superfamily (mfs).
DR PhosphoSite; P11169; -.
DR DMDM; 121760; -.
DR PaxDb; P11169; -.
DR PRIDE; P11169; -.
DR DNASU; 6515; -.
DR Ensembl; ENST00000075120; ENSP00000075120; ENSG00000059804.
DR GeneID; 6515; -.
DR KEGG; hsa:6515; -.
DR UCSC; uc001qtr.3; human.
DR CTD; 6515; -.
DR GeneCards; GC12M008071; -.
DR HGNC; HGNC:11007; SLC2A3.
DR HPA; CAB002763; -.
DR HPA; HPA006539; -.
DR MIM; 138170; gene.
DR neXtProt; NX_P11169; -.
DR PharmGKB; PA35877; -.
DR eggNOG; COG0477; -.
DR HOGENOM; HOG000202871; -.
DR HOVERGEN; HBG014816; -.
DR InParanoid; P11169; -.
DR KO; K08142; -.
DR OMA; FRAPSYR; -.
DR OrthoDB; EOG7QVM2R; -.
DR PhylomeDB; P11169; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR GenomeRNAi; 6515; -.
DR NextBio; 25335; -.
DR PRO; PR:P11169; -.
DR ArrayExpress; P11169; -.
DR Bgee; P11169; -.
DR CleanEx; HS_SLC2A3; -.
DR Genevestigator; P11169; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0019852; P:L-ascorbic acid metabolic process; TAS:Reactome.
DR InterPro; IPR002945; Glc_transpt_3.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR01192; GLUCTRSPORT3.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 496 Solute carrier family 2, facilitated
FT glucose transporter member 3.
FT /FTId=PRO_0000050353.
FT TOPO_DOM 1 5 Cytoplasmic (Potential).
FT TRANSMEM 6 26 Helical; Name=1; (Potential).
FT TOPO_DOM 27 64 Extracellular (Potential).
FT TRANSMEM 65 85 Helical; Name=2; (Potential).
FT TOPO_DOM 86 93 Cytoplasmic (Potential).
FT TRANSMEM 94 114 Helical; Name=3; (Potential).
FT TOPO_DOM 115 124 Extracellular (Potential).
FT TRANSMEM 125 145 Helical; Name=4; (Potential).
FT TOPO_DOM 146 153 Cytoplasmic (Potential).
FT TRANSMEM 154 174 Helical; Name=5; (Potential).
FT TOPO_DOM 175 183 Extracellular (Potential).
FT TRANSMEM 184 204 Helical; Name=6; (Potential).
FT TOPO_DOM 205 269 Cytoplasmic (Potential).
FT TRANSMEM 270 290 Helical; Name=7; (Potential).
FT TOPO_DOM 291 304 Extracellular (Potential).
FT TRANSMEM 305 325 Helical; Name=8; (Potential).
FT TOPO_DOM 326 334 Cytoplasmic (Potential).
FT TRANSMEM 335 355 Helical; Name=9; (Potential).
FT TOPO_DOM 356 368 Extracellular (Potential).
FT TRANSMEM 369 389 Helical; Name=10; (Potential).
FT TOPO_DOM 390 399 Cytoplasmic (Potential).
FT TRANSMEM 400 420 Helical; Name=11; (Potential).
FT TOPO_DOM 421 427 Extracellular (Potential).
FT TRANSMEM 428 448 Helical; Name=12; (Potential).
FT TOPO_DOM 449 496 Cytoplasmic (Potential).
FT REGION 277 279 Defines substrate specificity (By
FT similarity).
FT CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
FT VARIANT 85 85 V -> L (in dbSNP:rs17728193).
FT /FTId=VAR_052502.
SQ SEQUENCE 496 AA; 53924 MW; F601CD6892F16516 CRC64;
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML
ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS
EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ
EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN
GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF
PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV
MEMNSIEPAK ETTTNV
//
ID GTR3_HUMAN Reviewed; 496 AA.
AC P11169; B2R606; D3DUU6; Q6I9U2; Q9UG15;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUL-1989, sequence version 1.
DT 22-JAN-2014, entry version 146.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 3;
DE AltName: Full=Glucose transporter type 3, brain;
DE Short=GLUT-3;
GN Name=SLC2A3; Synonyms=GLUT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fetal skeletal muscle;
RX PubMed=3170580;
RA Kayano T., Fukumoto H., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B.,
RA Bell G.I.;
RT "Evidence for a family of human glucose transporter-like proteins.
RT Sequence and gene localization of a protein expressed in fetal
RT skeletal muscle and other tissues.";
RL J. Biol. Chem. 263:15245-15248(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Stuart C.A., Wen K.G., Acosta M., Wood T.G.;
RT "Resistance and expression of glucose transporters in human skeletal
RT muscle.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Duodenum;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 302-453.
RC TISSUE=Articular cartilage;
RA Neama G., Richardson S., Bell S., Carter S., Mobasheri A.;
RT "Molecular characterization and cloning of glucose transporters in
RT human articular chondrocytes.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP SUBSTRATE SPECIFICITY SITE.
RX PubMed=9477959; DOI=10.1021/bi972322u;
RA Seatter M.J., de la Rue S.A., Porter L.M., Gould G.W.;
RT "QLS motif in transmembrane helix VII of the glucose transporter
RT family interacts with the C-1 (position) of D-glucose and is involved
RT in substrate selection at the exofacial binding site.";
RL Biochemistry 37:1322-1326(1998).
CC -!- FUNCTION: Facilitative glucose transporter. Probably a neuronal
CC glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Highly expressed in brain. Expressed in many
CC tissues.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; M20681; AAB61083.1; -; mRNA.
DR EMBL; AF274892; AAF82116.1; -; Genomic_DNA.
DR EMBL; AF274889; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; AF274890; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; AF274891; AAF82116.1; JOINED; Genomic_DNA.
DR EMBL; CR457413; CAG33694.1; -; mRNA.
DR EMBL; AK312386; BAG35303.1; -; mRNA.
DR EMBL; CH471116; EAW88644.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88645.1; -; Genomic_DNA.
DR EMBL; BC039196; AAH39196.1; -; mRNA.
DR EMBL; AY034634; AAK56796.1; -; mRNA.
DR PIR; A31986; A31986.
DR PIR; T14798; T14798.
DR RefSeq; NP_008862.1; NM_006931.2.
DR UniGene; Hs.419240; -.
DR ProteinModelPortal; P11169; -.
DR SMR; P11169; 9-466.
DR IntAct; P11169; 4.
DR MINT; MINT-4999361; -.
DR STRING; 9606.ENSP00000075120; -.
DR ChEMBL; CHEMBL5215; -.
DR GuidetoPHARMACOLOGY; 877; -.
DR TCDB; 2.A.1.1.91; the major facilitator superfamily (mfs).
DR PhosphoSite; P11169; -.
DR DMDM; 121760; -.
DR PaxDb; P11169; -.
DR PRIDE; P11169; -.
DR DNASU; 6515; -.
DR Ensembl; ENST00000075120; ENSP00000075120; ENSG00000059804.
DR GeneID; 6515; -.
DR KEGG; hsa:6515; -.
DR UCSC; uc001qtr.3; human.
DR CTD; 6515; -.
DR GeneCards; GC12M008071; -.
DR HGNC; HGNC:11007; SLC2A3.
DR HPA; CAB002763; -.
DR HPA; HPA006539; -.
DR MIM; 138170; gene.
DR neXtProt; NX_P11169; -.
DR PharmGKB; PA35877; -.
DR eggNOG; COG0477; -.
DR HOGENOM; HOG000202871; -.
DR HOVERGEN; HBG014816; -.
DR InParanoid; P11169; -.
DR KO; K08142; -.
DR OMA; FRAPSYR; -.
DR OrthoDB; EOG7QVM2R; -.
DR PhylomeDB; P11169; -.
DR Reactome; REACT_111217; Metabolism.
DR Reactome; REACT_116125; Disease.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR GenomeRNAi; 6515; -.
DR NextBio; 25335; -.
DR PRO; PR:P11169; -.
DR ArrayExpress; P11169; -.
DR Bgee; P11169; -.
DR CleanEx; HS_SLC2A3; -.
DR Genevestigator; P11169; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0005355; F:glucose transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0019852; P:L-ascorbic acid metabolic process; TAS:Reactome.
DR InterPro; IPR002945; Glc_transpt_3.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR InterPro; IPR005828; Sub_transporter.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR01192; GLUCTRSPORT3.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 2.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Glycoprotein; Membrane; Polymorphism;
KW Reference proteome; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1 496 Solute carrier family 2, facilitated
FT glucose transporter member 3.
FT /FTId=PRO_0000050353.
FT TOPO_DOM 1 5 Cytoplasmic (Potential).
FT TRANSMEM 6 26 Helical; Name=1; (Potential).
FT TOPO_DOM 27 64 Extracellular (Potential).
FT TRANSMEM 65 85 Helical; Name=2; (Potential).
FT TOPO_DOM 86 93 Cytoplasmic (Potential).
FT TRANSMEM 94 114 Helical; Name=3; (Potential).
FT TOPO_DOM 115 124 Extracellular (Potential).
FT TRANSMEM 125 145 Helical; Name=4; (Potential).
FT TOPO_DOM 146 153 Cytoplasmic (Potential).
FT TRANSMEM 154 174 Helical; Name=5; (Potential).
FT TOPO_DOM 175 183 Extracellular (Potential).
FT TRANSMEM 184 204 Helical; Name=6; (Potential).
FT TOPO_DOM 205 269 Cytoplasmic (Potential).
FT TRANSMEM 270 290 Helical; Name=7; (Potential).
FT TOPO_DOM 291 304 Extracellular (Potential).
FT TRANSMEM 305 325 Helical; Name=8; (Potential).
FT TOPO_DOM 326 334 Cytoplasmic (Potential).
FT TRANSMEM 335 355 Helical; Name=9; (Potential).
FT TOPO_DOM 356 368 Extracellular (Potential).
FT TRANSMEM 369 389 Helical; Name=10; (Potential).
FT TOPO_DOM 390 399 Cytoplasmic (Potential).
FT TRANSMEM 400 420 Helical; Name=11; (Potential).
FT TOPO_DOM 421 427 Extracellular (Potential).
FT TRANSMEM 428 448 Helical; Name=12; (Potential).
FT TOPO_DOM 449 496 Cytoplasmic (Potential).
FT REGION 277 279 Defines substrate specificity (By
FT similarity).
FT CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).
FT VARIANT 85 85 V -> L (in dbSNP:rs17728193).
FT /FTId=VAR_052502.
SQ SEQUENCE 496 AA; 53924 MW; F601CD6892F16516 CRC64;
MGTQKVTPAL IFAITVATIG SFQFGYNTGV INAPEKIIKE FINKTLTDKG NAPPSEVLLT
SLWSLSVAIF SVGGMIGSFS VGLFVNRFGR RNSMLIVNLL AVTGGCFMGL CKVAKSVEML
ILGRLVIGLF CGLCTGFVPM YIGEISPTAL RGAFGTLNQL GIVVGILVAQ IFGLEFILGS
EELWPLLLGF TILPAILQSA ALPFCPESPR FLLINRKEEE NAKQILQRLW GTQDVSQDIQ
EMKDESARMS QEKQVTVLEL FRVSSYRQPI IISIVLQLSQ QLSGINAVFY YSTGIFKDAG
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAFCSTLMT VSLLLKDNYN
GMSFVCIGAI LVFVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGLLF
PSAAHYLGAY VFIIFTGFLI TFLAFTFFKV PETRGRTFED ITRAFEGQAH GADRSGKDGV
MEMNSIEPAK ETTTNV
//
MIM
138170
*RECORD*
*FIELD* NO
138170
*FIELD* TI
*138170 SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
3; SLC2A3
read more;;GLUCOSE TRANSPORTER 3; GLUT3;;
GLUCOSE TRANSPORTER, FETAL SKELETAL MUSCLE
SOLUTE CARRIER FAMILY 2, MEMBER 3 PSEUDOGENE, INCLUDED; SLC2A3P, INCLUDED;;
GLUCOSE TRANSPORTER 3 PSEUDOGENE 1, INCLUDED; GLUT3P1, INCLUDED
*FIELD* TX
CLONING
The mRNA levels encoding glucose transporter (see SLC2A1; 138140 and
SLC2A2; 138160) are very low in skeletal muscle, an important site of
peripheral glucose uptake and utilization, suggesting that another
protein may be responsible for glucose uptake by this tissue. Reasoning
that there might be a family of structurally related glucose transport
proteins in mammalian cells, just as there is a family of related
proteins involved in sugar and nutrient uptake in Escherichia coli,
Kayano et al. (1988) screened a human fetal skeletal muscle cDNA library
using low-stringency conditions to identify clones that cross-hybridize
with a hepatoma-derived glucose transporter cDNA. The mRNA encoding this
protein was present in most if not all tissues, although the amounts
varied widely. The 496-amino acid fetal muscle glucose transporter-like
protein shares 64.4% and 51.6% identity with the previously described
GLUT1 (138140) and GLUT2 (138160) sequences, respectively.
- PSEUDOGENE
By the homology screening approach, Kayano et al. (1990) identified a
glucose transporter-like transcript, called GLUT6 by them, with an
apparently ubiquitous tissue distribution. Sequence analysis of a cDNA
clone for this transcript revealed a high level of base identity (79.6%)
with GLUT3. However, the cDNA was found to contain multiple stop codons
and frameshifts, indicating that it probably does not encode a
functional glucose transporter. The extensive identity of the GLUT6 cDNA
with the GLUT3 cDNA sequence suggested that the GLUT-like region of the
GLUT6 transcript may have arisen by the insertion of a
reverse-transcribed copy of GLUT3 into the noncoding region of a
ubiquitously expressed gene--a 'hitchhiking' phenomenon. (This
pseudogene is also symbolized SLC2A3P and GLUT3P1.)
GENE FUNCTION
Gould and Holman (1993), who provided a review of the glucose
transporter family, referred to GLUT3 as the brain-type glucose
transporter. It appears that high GLUT3 protein expression is confined
generally to tissues that exhibit a high glucose demand, such as brain
and nerve. Hauguel-de Mouzon et al. (1997) examined the cellular
localization of GLUT3 mRNA and protein. In situ hybridization showed
that GLUT3 mRNA was present in the trophoblast cell layer and in
vascular endothelium with a heterogeneous distribution pattern. GLUT3
protein, migrating at an apparent molecular mass of 49 kD, was detected
by immunoblotting in membranes from whole placenta and endothelial cells
derived from intraplacental microvessels, but not in isolated
trophoblast cells. This cell-specific pattern of expression was
confirmed by immunocytochemical studies showing localization of GLUT3
protein in vascular endothelium. Based on the cell-specific distribution
of GLUT3 protein at the fetal interface, the authors suggested that this
protein may be important in the transport of glucose from the placenta
to the fetal circulation.
MAPPING
By in situ hybridization to metaphase chromosomes, Kayano et al. (1988)
assigned the gene encoding this protein to 12p13.3.
- PSEUDOGENE
By hybridization of a cDNA probe to a panel of somatic cell hybrids and
by in situ hybridization, Fan et al. (1989) showed that the GLUT3
pseudogene GLUT6 is located on chromosome 5.
*FIELD* RF
1. Fan, Y.-S.; Eddy, R. L.; Byers, M. G.; Haley, L. L.; Henry, W.
M.; Kayano, T.; Shows, T. B.; Bell, G. I.: Assignment of genes encoding
three human glucose transporter/transporter-like proteins (GLUT4,
GLUT5 and GLUT6) to chromosomes 17, 1 and 5, respectively. (Abstract) Cytogenet.
Cell Genet. 51: 997 only, 1989.
2. Gould, G. W.; Holman, G. D.: The glucose transporter family: structure,
function and tissue-specific expression. Biochem. J. 295: 329-341,
1993.
3. Hauguel-de Mouzon, S.; Challier, J. C.; Kacemi, A.; Cauzac, M.;
Malek, A.; Girard, J.: The GLUT3 glucose transporter isoform is differentially
expressed within human placental cell types. J. Clin. Endocr. Metab. 82:
2689-2694, 1997.
4. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y.
S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I.
: Human facilitative glucose transporters: isolation, functional characterization,
and gene localization of cDNAs encoding an isoform (GLUT5) expressed
in small intestine, kidney, muscle, and adipose tissue and an unusual
glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265:
13276-13282, 1990.
5. Kayano, T.; Fukumoto, H.; Eddy, R. L.; Fan, Y.-S.; Byers, M. G.;
Shows, T. B.; Bell, G. I.: Evidence for a family of human glucose
transporter-like proteins: sequence and gene localization of a protein
expressed in fetal skeletal muscle and other tissues. J. Biol. Chem. 263:
15245-15248, 1988.
*FIELD* CN
John A. Phillips, III - updated: 9/18/1997
Victor A. McKusick - edited: 2/21/1997
*FIELD* CD
Victor A. McKusick: 11/23/1988
*FIELD* ED
alopez: 05/21/2010
carol: 3/8/2002
terry: 3/8/2002
dkim: 7/21/1998
dholmes: 11/11/1997
dholmes: 10/30/1997
dholmes: 10/29/1997
alopez: 6/4/1997
mark: 3/14/1997
mark: 2/21/1997
mimadm: 9/24/1994
carol: 3/18/1994
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/27/1989
root: 11/23/1988
*RECORD*
*FIELD* NO
138170
*FIELD* TI
*138170 SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
3; SLC2A3
read more;;GLUCOSE TRANSPORTER 3; GLUT3;;
GLUCOSE TRANSPORTER, FETAL SKELETAL MUSCLE
SOLUTE CARRIER FAMILY 2, MEMBER 3 PSEUDOGENE, INCLUDED; SLC2A3P, INCLUDED;;
GLUCOSE TRANSPORTER 3 PSEUDOGENE 1, INCLUDED; GLUT3P1, INCLUDED
*FIELD* TX
CLONING
The mRNA levels encoding glucose transporter (see SLC2A1; 138140 and
SLC2A2; 138160) are very low in skeletal muscle, an important site of
peripheral glucose uptake and utilization, suggesting that another
protein may be responsible for glucose uptake by this tissue. Reasoning
that there might be a family of structurally related glucose transport
proteins in mammalian cells, just as there is a family of related
proteins involved in sugar and nutrient uptake in Escherichia coli,
Kayano et al. (1988) screened a human fetal skeletal muscle cDNA library
using low-stringency conditions to identify clones that cross-hybridize
with a hepatoma-derived glucose transporter cDNA. The mRNA encoding this
protein was present in most if not all tissues, although the amounts
varied widely. The 496-amino acid fetal muscle glucose transporter-like
protein shares 64.4% and 51.6% identity with the previously described
GLUT1 (138140) and GLUT2 (138160) sequences, respectively.
- PSEUDOGENE
By the homology screening approach, Kayano et al. (1990) identified a
glucose transporter-like transcript, called GLUT6 by them, with an
apparently ubiquitous tissue distribution. Sequence analysis of a cDNA
clone for this transcript revealed a high level of base identity (79.6%)
with GLUT3. However, the cDNA was found to contain multiple stop codons
and frameshifts, indicating that it probably does not encode a
functional glucose transporter. The extensive identity of the GLUT6 cDNA
with the GLUT3 cDNA sequence suggested that the GLUT-like region of the
GLUT6 transcript may have arisen by the insertion of a
reverse-transcribed copy of GLUT3 into the noncoding region of a
ubiquitously expressed gene--a 'hitchhiking' phenomenon. (This
pseudogene is also symbolized SLC2A3P and GLUT3P1.)
GENE FUNCTION
Gould and Holman (1993), who provided a review of the glucose
transporter family, referred to GLUT3 as the brain-type glucose
transporter. It appears that high GLUT3 protein expression is confined
generally to tissues that exhibit a high glucose demand, such as brain
and nerve. Hauguel-de Mouzon et al. (1997) examined the cellular
localization of GLUT3 mRNA and protein. In situ hybridization showed
that GLUT3 mRNA was present in the trophoblast cell layer and in
vascular endothelium with a heterogeneous distribution pattern. GLUT3
protein, migrating at an apparent molecular mass of 49 kD, was detected
by immunoblotting in membranes from whole placenta and endothelial cells
derived from intraplacental microvessels, but not in isolated
trophoblast cells. This cell-specific pattern of expression was
confirmed by immunocytochemical studies showing localization of GLUT3
protein in vascular endothelium. Based on the cell-specific distribution
of GLUT3 protein at the fetal interface, the authors suggested that this
protein may be important in the transport of glucose from the placenta
to the fetal circulation.
MAPPING
By in situ hybridization to metaphase chromosomes, Kayano et al. (1988)
assigned the gene encoding this protein to 12p13.3.
- PSEUDOGENE
By hybridization of a cDNA probe to a panel of somatic cell hybrids and
by in situ hybridization, Fan et al. (1989) showed that the GLUT3
pseudogene GLUT6 is located on chromosome 5.
*FIELD* RF
1. Fan, Y.-S.; Eddy, R. L.; Byers, M. G.; Haley, L. L.; Henry, W.
M.; Kayano, T.; Shows, T. B.; Bell, G. I.: Assignment of genes encoding
three human glucose transporter/transporter-like proteins (GLUT4,
GLUT5 and GLUT6) to chromosomes 17, 1 and 5, respectively. (Abstract) Cytogenet.
Cell Genet. 51: 997 only, 1989.
2. Gould, G. W.; Holman, G. D.: The glucose transporter family: structure,
function and tissue-specific expression. Biochem. J. 295: 329-341,
1993.
3. Hauguel-de Mouzon, S.; Challier, J. C.; Kacemi, A.; Cauzac, M.;
Malek, A.; Girard, J.: The GLUT3 glucose transporter isoform is differentially
expressed within human placental cell types. J. Clin. Endocr. Metab. 82:
2689-2694, 1997.
4. Kayano, T.; Burant, C. F.; Fukumoto, H.; Gould, G. W.; Fan, Y.
S.; Eddy, R. L.; Byers, M. G.; Shows, T. B.; Seino, S.; Bell, G. I.
: Human facilitative glucose transporters: isolation, functional characterization,
and gene localization of cDNAs encoding an isoform (GLUT5) expressed
in small intestine, kidney, muscle, and adipose tissue and an unusual
glucose transporter pseudogene-like sequence (GLUT6). J. Biol. Chem. 265:
13276-13282, 1990.
5. Kayano, T.; Fukumoto, H.; Eddy, R. L.; Fan, Y.-S.; Byers, M. G.;
Shows, T. B.; Bell, G. I.: Evidence for a family of human glucose
transporter-like proteins: sequence and gene localization of a protein
expressed in fetal skeletal muscle and other tissues. J. Biol. Chem. 263:
15245-15248, 1988.
*FIELD* CN
John A. Phillips, III - updated: 9/18/1997
Victor A. McKusick - edited: 2/21/1997
*FIELD* CD
Victor A. McKusick: 11/23/1988
*FIELD* ED
alopez: 05/21/2010
carol: 3/8/2002
terry: 3/8/2002
dkim: 7/21/1998
dholmes: 11/11/1997
dholmes: 10/30/1997
dholmes: 10/29/1997
alopez: 6/4/1997
mark: 3/14/1997
mark: 2/21/1997
mimadm: 9/24/1994
carol: 3/18/1994
supermim: 3/16/1992
supermim: 3/20/1990
ddp: 10/27/1989
root: 11/23/1988