Full text data of HRH4
HRH4
(GPCR105)
[Confidence: low (only semi-automatic identification from reviews)]
Histamine H4 receptor; H4R; HH4R (AXOR35; G-protein coupled receptor 105; GPRv53; Pfi-013; SP9144)
Histamine H4 receptor; H4R; HH4R (AXOR35; G-protein coupled receptor 105; GPRv53; Pfi-013; SP9144)
UniProt
Q9H3N8
ID HRH4_HUMAN Reviewed; 390 AA.
AC Q9H3N8; B0YJ19; B2KJ48; Q4G0I6; Q9GZQ0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 2.
DT 22-JAN-2014, entry version 124.
DE RecName: Full=Histamine H4 receptor;
DE Short=H4R;
DE Short=HH4R;
DE AltName: Full=AXOR35;
DE AltName: Full=G-protein coupled receptor 105;
DE AltName: Full=GPRv53;
DE AltName: Full=Pfi-013;
DE AltName: Full=SP9144;
GN Name=HRH4; Synonyms=GPCR105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS VAL-138 AND
RP ARG-206.
RX PubMed=10973974; DOI=10.1074/jbc.M006480200;
RA Oda T., Morikawa N., Saito Y., Masuho Y., Matsumoto S.;
RT "Molecular cloning and characterization of a novel type of histamine
RT receptor preferentially expressed in leukocytes.";
RL J. Biol. Chem. 275:36781-36786(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Leukocyte;
RX PubMed=11118334; DOI=10.1006/bbrc.2000.4008;
RA Nakamura T., Itadani H., Hidaka Y., Ohta M., Tanaka K.;
RT "Molecular cloning and characterization of a new human histamine
RT receptor, HH4R.";
RL Biochem. Biophys. Res. Commun. 279:615-620(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Jones P.G., Wu S., Betty M.;
RT "Cloning of a novel histamine receptor.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Bone marrow;
RX PubMed=11179434;
RA Liu C., Ma X.-J., Jiang X., Wilson S.J., Hofstra C.L., Blevitt J.,
RA Pyati J., Li X., Chai W., Carruthers N., Lovenberg T.W.;
RT "Cloning and pharmacological characterization of a fourth histamine
RT receptor (H4) expressed in bone marrow.";
RL Mol. Pharmacol. 59:420-426(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Eosinophil;
RX PubMed=11181941;
RA Morse K.L., Behan J., Laz T.M., West R.E. Jr., Greenfeder S.A.,
RA Anthes J.C., Umland S., Wan Y., Hipkin R.W., Gonsiorek W., Shin N.,
RA Gustafson E.L., Qiao X., Wang S., Hedrick J.A., Greene J., Bayne M.,
RA Monsma F.J. Jr.;
RT "Cloning and characterization of a novel human histamine receptor.";
RL J. Pharmacol. Exp. Ther. 296:1058-1066(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11179436;
RA Zhu Y., Michalovich D., Wu H.-L., Tan K.B., Dytko G.M., Mannan I.J.,
RA Boyce R., Alston J., Tierney L.A., Li X., Herrity N.C., Vawter L.,
RA Sarau H.M., Ames R.S., Davenport C.M., Hieble P., Wilson S.,
RA Bergsma D.J., Fitzgerald L.R.;
RT "Cloning, expression, and pharmacological characterization of a novel
RT human histamine receptor.";
RL Mol. Pharmacol. 59:434-441(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=12503632; DOI=10.1081/RRS-120014612;
RA O'Reilly M.A., Alpert R., Jenkinson S., Gladue R.P., Foo S., Trim S.,
RA Peter B., Trevethick M., Fidock M.;
RT "Identification of a histamine H4 receptor on human eosinophils --role
RT in eosinophil chemotaxis.";
RL J. Recept. Signal Transduct. 22:431-448(2002).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Umbilical cord blood;
RX PubMed=18452403; DOI=10.1042/BJ20071583;
RA van Rijn R.M., van Marle A., Chazot P.L., Langemeijer E., Qin Y.,
RA Shenton F.C., Lim H.D., Zuiderveld O.P., Sansuk K., Dy M., Smit M.J.,
RA Tensen C.P., Bakker R.A., Leurs R.;
RT "Cloning and characterization of dominant negative splice variants of
RT the human histamine H4 receptor.";
RL Biochem. J. 414:121-131(2008).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction
RT sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G;);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The H4 subclass of histamine receptors could mediate the
CC histamine signals in peripheral tissues. Displays a significant
CC level of constitutive activity (spontaneous activity in the
CC absence of agonist).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H3N8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H3N8-2; Sequence=VSP_042737;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed primarily in the bone marrow and
CC eosinophils. Shows preferential distribution in cells of
CC immunological relevance such as T-cells, dendritic cells,
CC monocytes, mast cells, neutrophils. Also expressed in a wide
CC variety of peripheral tissues, including the heart, kidney, liver,
CC lung, pancreas, skeletal muscle, prostate, small intestine,
CC spleen, testis, colon, fetal liver and lymph node.
CC -!- INDUCTION: Expression is either up-regulated or down-regulated
CC upon activation of the lymphoid tissues and this regulation may
CC depend on the presence of IL10/interleukin-10 or IL13/interleukin-
CC 13.
CC -!- MISCELLANEOUS: Does not bind diphenhydramine, loratadine,
CC ranitidine, cimetidine and chlorpheniramine. Shows modest affinity
CC for dimaprit, impromidine, clobenpropit, thioperamide, burimamide
CC clozapine, immepip and imetit. The order of inhibitory activity
CC was imetit > clobenpropit > burimamide > thioperamide.
CC Clobenpropit behaves as a partial agonist, dimaprit and
CC impromidine show some agonist activity while clozapine behaves as
CC a full agonist. Thioperamide shows inverse agonism (enhances cAMP
CC activity). The order of inhibitory activity of histamine
CC derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha-
CC methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha-
CC methylhistamine > R(-)-alpha-methylhistamine behave as full
CC agonists.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; AB044934; BAB13698.1; -; mRNA.
DR EMBL; AB045370; BAB20091.1; -; mRNA.
DR EMBL; AF307973; AAG32052.1; -; mRNA.
DR EMBL; AF312230; AAK12081.1; -; mRNA.
DR EMBL; AF329449; AAK43542.1; -; mRNA.
DR EMBL; AF325356; AAL01684.1; -; mRNA.
DR EMBL; AJ298292; CAC83493.1; -; mRNA.
DR EMBL; DQ835186; ABI54174.1; -; mRNA.
DR EMBL; AY136745; AAN01271.1; -; mRNA.
DR EMBL; EF444982; ACA05997.1; -; Genomic_DNA.
DR EMBL; AC007922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471088; EAX01189.1; -; Genomic_DNA.
DR EMBL; BC069136; AAH69136.1; -; mRNA.
DR EMBL; BC112348; AAI12349.1; -; mRNA.
DR PIR; JC7566; JC7566.
DR RefSeq; NP_001137300.1; NM_001143828.1.
DR RefSeq; NP_001153638.1; NM_001160166.1.
DR RefSeq; NP_067637.2; NM_021624.3.
DR UniGene; Hs.287388; -.
DR ProteinModelPortal; Q9H3N8; -.
DR SMR; Q9H3N8; 16-372.
DR STRING; 9606.ENSP00000256906; -.
DR BindingDB; Q9H3N8; -.
DR ChEMBL; CHEMBL3759; -.
DR DrugBank; DB00363; Clozapine.
DR GuidetoPHARMACOLOGY; 265; -.
DR DMDM; 14194819; -.
DR PaxDb; Q9H3N8; -.
DR PRIDE; Q9H3N8; -.
DR Ensembl; ENST00000256906; ENSP00000256906; ENSG00000134489.
DR Ensembl; ENST00000426880; ENSP00000402526; ENSG00000134489.
DR GeneID; 59340; -.
DR KEGG; hsa:59340; -.
DR UCSC; uc002kvi.3; human.
DR CTD; 59340; -.
DR GeneCards; GC18P022040; -.
DR HGNC; HGNC:17383; HRH4.
DR HPA; HPA035009; -.
DR MIM; 606792; gene.
DR neXtProt; NX_Q9H3N8; -.
DR PharmGKB; PA134982275; -.
DR eggNOG; NOG289713; -.
DR HOGENOM; HOG000048707; -.
DR HOVERGEN; HBG102132; -.
DR InParanoid; Q9H3N8; -.
DR KO; K04152; -.
DR OMA; IAFWLQW; -.
DR OrthoDB; EOG7XWPNM; -.
DR PhylomeDB; Q9H3N8; -.
DR Reactome; REACT_111102; Signal Transduction.
DR GeneWiki; Histamine_H4_receptor; -.
DR GenomeRNAi; 59340; -.
DR NextBio; 65224; -.
DR PRO; PR:Q9H3N8; -.
DR Bgee; Q9H3N8; -.
DR CleanEx; HS_HRH4; -.
DR Genevestigator; Q9H3N8; -.
DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004969; F:histamine receptor activity; NAS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008102; Histamine_H4_rcpt.
DR PANTHER; PTHR24249:SF55; PTHR24249:SF55; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01726; HISTAMINEH4R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Complete proteome;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Polymorphism; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 390 Histamine H4 receptor.
FT /FTId=PRO_0000069693.
FT TOPO_DOM 1 19 Extracellular (Potential).
FT TRANSMEM 20 40 Helical; Name=1; (Potential).
FT TOPO_DOM 41 52 Cytoplasmic (Potential).
FT TRANSMEM 53 73 Helical; Name=2; (Potential).
FT TOPO_DOM 74 87 Extracellular (Potential).
FT TRANSMEM 88 108 Helical; Name=3; (Potential).
FT TOPO_DOM 109 131 Cytoplasmic (Potential).
FT TRANSMEM 132 152 Helical; Name=4; (Potential).
FT TOPO_DOM 153 172 Extracellular (Potential).
FT TRANSMEM 173 193 Helical; Name=5; (Potential).
FT TOPO_DOM 194 304 Cytoplasmic (Potential).
FT TRANSMEM 305 325 Helical; Name=6; (Potential).
FT TOPO_DOM 326 341 Extracellular (Potential).
FT TRANSMEM 342 362 Helical; Name=7; (Potential).
FT TOPO_DOM 363 390 Cytoplasmic (Potential).
FT LIPID 374 374 S-palmitoyl cysteine (Potential).
FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential).
FT DISULFID 87 164 By similarity.
FT VAR_SEQ 65 152 Missing (in isoform 2).
FT /FTId=VSP_042737.
FT VARIANT 138 138 A -> V (in dbSNP:rs11665084).
FT /FTId=VAR_033477.
FT VARIANT 206 206 H -> R (in dbSNP:rs11662595).
FT /FTId=VAR_033478.
FT CONFLICT 253 253 Q -> R (in Ref. 1; BAB13698).
SQ SEQUENCE 390 AA; 44496 MW; C986B8AE7FF912C3 CRC64;
MPDTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS SYFFLNLAIS
DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA SVYNIVLISY DRYLSVSNAV
SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM ILVSESWKDE GSECEPGFFS EWYILAITSF
LEFVIPVILV AYFNMNIYWS LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA
STEVPASFHS ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR
LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN SFVNPLLYPL
CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS
//
ID HRH4_HUMAN Reviewed; 390 AA.
AC Q9H3N8; B0YJ19; B2KJ48; Q4G0I6; Q9GZQ0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
read moreDT 01-JUN-2001, sequence version 2.
DT 22-JAN-2014, entry version 124.
DE RecName: Full=Histamine H4 receptor;
DE Short=H4R;
DE Short=HH4R;
DE AltName: Full=AXOR35;
DE AltName: Full=G-protein coupled receptor 105;
DE AltName: Full=GPRv53;
DE AltName: Full=Pfi-013;
DE AltName: Full=SP9144;
GN Name=HRH4; Synonyms=GPCR105;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS VAL-138 AND
RP ARG-206.
RX PubMed=10973974; DOI=10.1074/jbc.M006480200;
RA Oda T., Morikawa N., Saito Y., Masuho Y., Matsumoto S.;
RT "Molecular cloning and characterization of a novel type of histamine
RT receptor preferentially expressed in leukocytes.";
RL J. Biol. Chem. 275:36781-36786(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Leukocyte;
RX PubMed=11118334; DOI=10.1006/bbrc.2000.4008;
RA Nakamura T., Itadani H., Hidaka Y., Ohta M., Tanaka K.;
RT "Molecular cloning and characterization of a new human histamine
RT receptor, HH4R.";
RL Biochem. Biophys. Res. Commun. 279:615-620(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Jones P.G., Wu S., Betty M.;
RT "Cloning of a novel histamine receptor.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Bone marrow;
RX PubMed=11179434;
RA Liu C., Ma X.-J., Jiang X., Wilson S.J., Hofstra C.L., Blevitt J.,
RA Pyati J., Li X., Chai W., Carruthers N., Lovenberg T.W.;
RT "Cloning and pharmacological characterization of a fourth histamine
RT receptor (H4) expressed in bone marrow.";
RL Mol. Pharmacol. 59:420-426(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CHARACTERIZATION.
RC TISSUE=Eosinophil;
RX PubMed=11181941;
RA Morse K.L., Behan J., Laz T.M., West R.E. Jr., Greenfeder S.A.,
RA Anthes J.C., Umland S., Wan Y., Hipkin R.W., Gonsiorek W., Shin N.,
RA Gustafson E.L., Qiao X., Wang S., Hedrick J.A., Greene J., Bayne M.,
RA Monsma F.J. Jr.;
RT "Cloning and characterization of a novel human histamine receptor.";
RL J. Pharmacol. Exp. Ther. 296:1058-1066(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11179436;
RA Zhu Y., Michalovich D., Wu H.-L., Tan K.B., Dytko G.M., Mannan I.J.,
RA Boyce R., Alston J., Tierney L.A., Li X., Herrity N.C., Vawter L.,
RA Sarau H.M., Ames R.S., Davenport C.M., Hieble P., Wilson S.,
RA Bergsma D.J., Fitzgerald L.R.;
RT "Cloning, expression, and pharmacological characterization of a novel
RT human histamine receptor.";
RL Mol. Pharmacol. 59:434-441(2001).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=12503632; DOI=10.1081/RRS-120014612;
RA O'Reilly M.A., Alpert R., Jenkinson S., Gladue R.P., Foo S., Trim S.,
RA Peter B., Trevethick M., Fidock M.;
RT "Identification of a histamine H4 receptor on human eosinophils --role
RT in eosinophil chemotaxis.";
RL J. Recept. Signal Transduct. 22:431-448(2002).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Umbilical cord blood;
RX PubMed=18452403; DOI=10.1042/BJ20071583;
RA van Rijn R.M., van Marle A., Chazot P.L., Langemeijer E., Qin Y.,
RA Shenton F.C., Lim H.D., Zuiderveld O.P., Sansuk K., Dy M., Smit M.J.,
RA Tensen C.P., Bakker R.A., Leurs R.;
RT "Cloning and characterization of dominant negative splice variants of
RT the human histamine H4 receptor.";
RL Biochem. J. 414:121-131(2008).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction
RT sequenced by the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G;);
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [11]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [12]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [13]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: The H4 subclass of histamine receptors could mediate the
CC histamine signals in peripheral tissues. Displays a significant
CC level of constitutive activity (spontaneous activity in the
CC absence of agonist).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H3N8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H3N8-2; Sequence=VSP_042737;
CC Note=No experimental confirmation available;
CC -!- TISSUE SPECIFICITY: Expressed primarily in the bone marrow and
CC eosinophils. Shows preferential distribution in cells of
CC immunological relevance such as T-cells, dendritic cells,
CC monocytes, mast cells, neutrophils. Also expressed in a wide
CC variety of peripheral tissues, including the heart, kidney, liver,
CC lung, pancreas, skeletal muscle, prostate, small intestine,
CC spleen, testis, colon, fetal liver and lymph node.
CC -!- INDUCTION: Expression is either up-regulated or down-regulated
CC upon activation of the lymphoid tissues and this regulation may
CC depend on the presence of IL10/interleukin-10 or IL13/interleukin-
CC 13.
CC -!- MISCELLANEOUS: Does not bind diphenhydramine, loratadine,
CC ranitidine, cimetidine and chlorpheniramine. Shows modest affinity
CC for dimaprit, impromidine, clobenpropit, thioperamide, burimamide
CC clozapine, immepip and imetit. The order of inhibitory activity
CC was imetit > clobenpropit > burimamide > thioperamide.
CC Clobenpropit behaves as a partial agonist, dimaprit and
CC impromidine show some agonist activity while clozapine behaves as
CC a full agonist. Thioperamide shows inverse agonism (enhances cAMP
CC activity). The order of inhibitory activity of histamine
CC derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha-
CC methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha-
CC methylhistamine > R(-)-alpha-methylhistamine behave as full
CC agonists.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; AB044934; BAB13698.1; -; mRNA.
DR EMBL; AB045370; BAB20091.1; -; mRNA.
DR EMBL; AF307973; AAG32052.1; -; mRNA.
DR EMBL; AF312230; AAK12081.1; -; mRNA.
DR EMBL; AF329449; AAK43542.1; -; mRNA.
DR EMBL; AF325356; AAL01684.1; -; mRNA.
DR EMBL; AJ298292; CAC83493.1; -; mRNA.
DR EMBL; DQ835186; ABI54174.1; -; mRNA.
DR EMBL; AY136745; AAN01271.1; -; mRNA.
DR EMBL; EF444982; ACA05997.1; -; Genomic_DNA.
DR EMBL; AC007922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471088; EAX01189.1; -; Genomic_DNA.
DR EMBL; BC069136; AAH69136.1; -; mRNA.
DR EMBL; BC112348; AAI12349.1; -; mRNA.
DR PIR; JC7566; JC7566.
DR RefSeq; NP_001137300.1; NM_001143828.1.
DR RefSeq; NP_001153638.1; NM_001160166.1.
DR RefSeq; NP_067637.2; NM_021624.3.
DR UniGene; Hs.287388; -.
DR ProteinModelPortal; Q9H3N8; -.
DR SMR; Q9H3N8; 16-372.
DR STRING; 9606.ENSP00000256906; -.
DR BindingDB; Q9H3N8; -.
DR ChEMBL; CHEMBL3759; -.
DR DrugBank; DB00363; Clozapine.
DR GuidetoPHARMACOLOGY; 265; -.
DR DMDM; 14194819; -.
DR PaxDb; Q9H3N8; -.
DR PRIDE; Q9H3N8; -.
DR Ensembl; ENST00000256906; ENSP00000256906; ENSG00000134489.
DR Ensembl; ENST00000426880; ENSP00000402526; ENSG00000134489.
DR GeneID; 59340; -.
DR KEGG; hsa:59340; -.
DR UCSC; uc002kvi.3; human.
DR CTD; 59340; -.
DR GeneCards; GC18P022040; -.
DR HGNC; HGNC:17383; HRH4.
DR HPA; HPA035009; -.
DR MIM; 606792; gene.
DR neXtProt; NX_Q9H3N8; -.
DR PharmGKB; PA134982275; -.
DR eggNOG; NOG289713; -.
DR HOGENOM; HOG000048707; -.
DR HOVERGEN; HBG102132; -.
DR InParanoid; Q9H3N8; -.
DR KO; K04152; -.
DR OMA; IAFWLQW; -.
DR OrthoDB; EOG7XWPNM; -.
DR PhylomeDB; Q9H3N8; -.
DR Reactome; REACT_111102; Signal Transduction.
DR GeneWiki; Histamine_H4_receptor; -.
DR GenomeRNAi; 59340; -.
DR NextBio; 65224; -.
DR PRO; PR:Q9H3N8; -.
DR Bgee; Q9H3N8; -.
DR CleanEx; HS_HRH4; -.
DR Genevestigator; Q9H3N8; -.
DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004969; F:histamine receptor activity; NAS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR GO; GO:0043408; P:regulation of MAPK cascade; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008102; Histamine_H4_rcpt.
DR PANTHER; PTHR24249:SF55; PTHR24249:SF55; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01726; HISTAMINEH4R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Complete proteome;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Polymorphism; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 390 Histamine H4 receptor.
FT /FTId=PRO_0000069693.
FT TOPO_DOM 1 19 Extracellular (Potential).
FT TRANSMEM 20 40 Helical; Name=1; (Potential).
FT TOPO_DOM 41 52 Cytoplasmic (Potential).
FT TRANSMEM 53 73 Helical; Name=2; (Potential).
FT TOPO_DOM 74 87 Extracellular (Potential).
FT TRANSMEM 88 108 Helical; Name=3; (Potential).
FT TOPO_DOM 109 131 Cytoplasmic (Potential).
FT TRANSMEM 132 152 Helical; Name=4; (Potential).
FT TOPO_DOM 153 172 Extracellular (Potential).
FT TRANSMEM 173 193 Helical; Name=5; (Potential).
FT TOPO_DOM 194 304 Cytoplasmic (Potential).
FT TRANSMEM 305 325 Helical; Name=6; (Potential).
FT TOPO_DOM 326 341 Extracellular (Potential).
FT TRANSMEM 342 362 Helical; Name=7; (Potential).
FT TOPO_DOM 363 390 Cytoplasmic (Potential).
FT LIPID 374 374 S-palmitoyl cysteine (Potential).
FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 9 9 N-linked (GlcNAc...) (Potential).
FT DISULFID 87 164 By similarity.
FT VAR_SEQ 65 152 Missing (in isoform 2).
FT /FTId=VSP_042737.
FT VARIANT 138 138 A -> V (in dbSNP:rs11665084).
FT /FTId=VAR_033477.
FT VARIANT 206 206 H -> R (in dbSNP:rs11662595).
FT /FTId=VAR_033478.
FT CONFLICT 253 253 Q -> R (in Ref. 1; BAB13698).
SQ SEQUENCE 390 AA; 44496 MW; C986B8AE7FF912C3 CRC64;
MPDTNSTINL SLSTRVTLAF FMSLVAFAIM LGNALVILAF VVDKNLRHRS SYFFLNLAIS
DFFVGVISIP LYIPHTLFEW DFGKEICVFW LTTDYLLCTA SVYNIVLISY DRYLSVSNAV
SYRTQHTGVL KIVTLMVAVW VLAFLVNGPM ILVSESWKDE GSECEPGFFS EWYILAITSF
LEFVIPVILV AYFNMNIYWS LWKRDHLSRC QSHPGLTAVS SNICGHSFRG RLSSRRSLSA
STEVPASFHS ERQRRKSSLM FSSRTKMNSN TIASKMGSFS QSDSVALHQR EHVELLRARR
LAKSLAILLG VFAVCWAPYS LFTIVLSFYS SATGPKSVWY RIAFWLQWFN SFVNPLLYPL
CHKRFQKAFL KIFCIKKQPL PSQHSRSVSS
//
MIM
606792
*RECORD*
*FIELD* NO
606792
*FIELD* TI
*606792 HISTAMINE RECEPTOR H4; HRH4
;;HH4R
*FIELD* TX
DESCRIPTION
Histamine receptors are G protein-coupled receptors (GPCRs) that have
read moredistinct tissue expression profiles and functional attributes. They have
varying sensitivities to an array of agonist and antagonist molecules
that are used in pharmacologic studies and in treating different medical
conditions (Nakamura et al., 2000).
CLONING
By database searching for GPCR-like sequences, followed by RACE, Oda et
al. (2000) obtained a cDNA encoding HRH4, which they termed GPRV53. The
deduced 390-amino acid protein is almost 40% identical to HRH3 (604525).
It contains an asp residue in transmembrane domain-1 (TM1), a DRY motif
in TM2, a disulfide bond between the first and third extracellular
loops, a trp in TM4 and TM6, a pro in TM5 and TM6, an NPxxY motif in
TM7, and a potential palmitoylation site in the C-terminal tail.
Northern blot analysis revealed expression of a 4.5-kb transcript
restricted to peripheral blood leukocytes. RT-PCR analysis detected
expression in thymus, small intestine, spleen, and colon. No expression
was detected in brain, where HRH3 expression is restricted. Within
blood, expression was most abundant in eosinophils.
Independently, Nguyen et al. (2001), Liu et al. (2001), Morse et al.
(2001), and Zhu et al. (2001) also cloned HRH4, which they termed H4,
GPCR105, SP9144, and AXOR35, respectively. Although these authors found
some functional and pharmacologic differences, the expression and
sequence data corresponded to the data reported by Oda et al. (2000)
except for 3 amino acid differences. Specifically, the ala138, his206,
and gln253 residues reported by these authors, which were also found in
the HH4R sequence published by Nakamura et al. (2000), were replaced
with a valine and 2 arginines, respectively, in the sequence reported by
Oda et al. (2000), suggesting sequencing errors or real variation in the
human population.
Liu et al. (2001) detected slight expression of HRH4 in brain, and Zhu
et al. (2001) demonstrated expression in mouse hippocampus by in situ
hybridization. Coge et al. (2001) detected expression in human lung,
hippocampus, and cerebellum by RT-PCR. Coge et al. (2001) and Liu et al.
(2001) estimated the mRNA transcript to be 3.7 kb.
GENE FUNCTION
Functional analysis by Oda et al. (2000) showed that expression of HRH4
conferred sensitivity, as measured by inhibition of cAMP accumulation,
to histamine but not to other biologic amines. HRH3 agonists, but not
HRH1 (600167) or HRH2 (142703) agonists, enhanced and HRH3 antagonists
blocked histamine activity in HRH4-expressing cells. The HRH3 ligands
and histamine competed for binding of radiolabeled histamine.
Nakamura et al. (2000) concluded that HRH4 may mediate signals in
peripheral tissues and thus have a somewhat different physiology,
particularly in immune regulation and inflammatory processes, from HRH3.
They suggested that different agonists and antagonists will be required
for therapy and biologic analysis.
Liu et al. (2001) cloned Hrh4 cDNAs from rat, mouse, and guinea pig, all
of which encode proteins less than 70% homologous to the human protein.
Most abundant expression was detected in bone marrow and spleen of these
species. The murine receptors had lower affinity for histamine than did
those of humans and guinea pigs, and there was even greater species
differences in binding and functional responses to pharmacologic
ligands. Liu et al. (2001) concluded that in vivo studies will be
difficult to interpret in the absence of selective and comparable HRH4
reagents.
GENE STRUCTURE
By genomic sequence analysis, Oda et al. (2000) determined that the HRH4
gene contains 3 exons.
Coge et al. (2001) found that the single-copy HRH4 gene spans more than
21 kb with the exons separated by 2 large (more than 7.0 kb) introns. It
encodes no apparent splice variants. The HRH4 promoter lacks TATA and
CAAT boxes and GC-rich regions, but contains multiple regulatory
elements, including sites for GATA1 (305371) and CEBPB (189965). There
is also a uteroglobin (UGB; 192020) promoter-binding factor, which is
known to mediate antiinflammatory responses in the lung.
MAPPING
By genomic sequence analysis, Oda et al. (2000) mapped the HRH4 gene to
chromosome 18q11.2. Coge et al. (2001) confirmed this localization by
radiation hybrid analysis.
*FIELD* RF
1. Coge, F.; Guenin, S.-P.; Rique, H.; Boutin, J. A.; Galizzi, J.-P.
: Structure and expression of the human histamine H(4)-receptor gene. Biochem.
Biophys. Res. Commun. 284: 301-309, 2001.
2. Liu, C.; Ma, X.-J.; Jiang, X.; Wilson, S. J.; Hofstra, C. L.; Blevitt,
J.; Pyati, J.; Li, X.; Chai, W.; Carruthers, N.; Lovenberg, T. W.
: Cloning and pharmacological characterization of a fourth histamine
receptor (H(4)) expressed in bone marrow. Molec. Pharm. 59: 420-426,
2001.
3. Liu, C.; Wilson, S. J.; Kuei, C.; Lovenberg, T. W.: Comparison
of human, mouse, rat, and guinea pig histamine H(4) receptors reveals
substantial pharmacological species variation. J. Pharm. Exp. Ther. 299:
121-130, 2001.
4. Morse, K. L.; Behan, J.; Laz, T. M.; West, R. E., Jr.; Greenfeder,
S. A.; Anthes, J. C.; Umland, S.; Wan, Y.; Hipkin, R. W.; Gonsiorek,
W.; Shin, N.; Gustafson, E. L.; Qiao, X.; Wang, S.; Hedrick, J. A.;
Greene, J.; Bayne, M.; Monsma, F. J., Jr.: Cloning and characterization
of a novel human histamine receptor. J. Pharm. Exp. Ther. 296: 1058-1066,
2001.
5. Nakamura, T.; Itadani, H.; Hidaka, Y.; Ohta, M.; Tanaka, K.: Molecular
cloning and characterization of a new human histamine receptor, HH4R. Biochem.
Biophys. Res. Commun. 279: 615-620, 2000.
6. Nguyen, T.; Shapiro, D. A.; George, S. R.; Setola, V.; Lee, D.
K.; Cheng, R.; Rauser, L.; Lee, S. P.; Lynch, K. R.; Roth, B. L.;
O'Dowd, B. F.: Discovery of a novel member of the histamine receptor
family. Molec. Pharm. 59: 427-433, 2001.
7. Oda, T.; Morikawa, N.; Saito, Y.; Masuho, Y.; Matsumoto, S.: Molecular
cloning and characterization of a novel type of histamine receptor
preferentially expressed in leukocytes. J. Biol. Chem. 275: 36781-36786,
2000.
8. Zhu, Y.; Michalovich, D.; Wu, H.-L.; Tan, K. B.; Dytko, G. M.;
Mannan, I. J.; Boyce, R.; Alston, J.; Tierney, L. A.; Li, X.; Herrity,
N. C.; Vawter, L.; Sarau, H. M.; Ames, R. S.; Davenport, C. M.; Hieble,
J. P.; Wilson, S.; Bergsma, D. J.; Fitzgerald, L. R.: Cloning, expression,
and pharmacological characterization of a novel histamine receptor. Molec.
Pharm. 59: 434-441, 2001.
*FIELD* CD
Paul J. Converse: 3/26/2002
*FIELD* ED
alopez: 12/16/2005
terry: 1/2/2003
mgross: 3/26/2002
*RECORD*
*FIELD* NO
606792
*FIELD* TI
*606792 HISTAMINE RECEPTOR H4; HRH4
;;HH4R
*FIELD* TX
DESCRIPTION
Histamine receptors are G protein-coupled receptors (GPCRs) that have
read moredistinct tissue expression profiles and functional attributes. They have
varying sensitivities to an array of agonist and antagonist molecules
that are used in pharmacologic studies and in treating different medical
conditions (Nakamura et al., 2000).
CLONING
By database searching for GPCR-like sequences, followed by RACE, Oda et
al. (2000) obtained a cDNA encoding HRH4, which they termed GPRV53. The
deduced 390-amino acid protein is almost 40% identical to HRH3 (604525).
It contains an asp residue in transmembrane domain-1 (TM1), a DRY motif
in TM2, a disulfide bond between the first and third extracellular
loops, a trp in TM4 and TM6, a pro in TM5 and TM6, an NPxxY motif in
TM7, and a potential palmitoylation site in the C-terminal tail.
Northern blot analysis revealed expression of a 4.5-kb transcript
restricted to peripheral blood leukocytes. RT-PCR analysis detected
expression in thymus, small intestine, spleen, and colon. No expression
was detected in brain, where HRH3 expression is restricted. Within
blood, expression was most abundant in eosinophils.
Independently, Nguyen et al. (2001), Liu et al. (2001), Morse et al.
(2001), and Zhu et al. (2001) also cloned HRH4, which they termed H4,
GPCR105, SP9144, and AXOR35, respectively. Although these authors found
some functional and pharmacologic differences, the expression and
sequence data corresponded to the data reported by Oda et al. (2000)
except for 3 amino acid differences. Specifically, the ala138, his206,
and gln253 residues reported by these authors, which were also found in
the HH4R sequence published by Nakamura et al. (2000), were replaced
with a valine and 2 arginines, respectively, in the sequence reported by
Oda et al. (2000), suggesting sequencing errors or real variation in the
human population.
Liu et al. (2001) detected slight expression of HRH4 in brain, and Zhu
et al. (2001) demonstrated expression in mouse hippocampus by in situ
hybridization. Coge et al. (2001) detected expression in human lung,
hippocampus, and cerebellum by RT-PCR. Coge et al. (2001) and Liu et al.
(2001) estimated the mRNA transcript to be 3.7 kb.
GENE FUNCTION
Functional analysis by Oda et al. (2000) showed that expression of HRH4
conferred sensitivity, as measured by inhibition of cAMP accumulation,
to histamine but not to other biologic amines. HRH3 agonists, but not
HRH1 (600167) or HRH2 (142703) agonists, enhanced and HRH3 antagonists
blocked histamine activity in HRH4-expressing cells. The HRH3 ligands
and histamine competed for binding of radiolabeled histamine.
Nakamura et al. (2000) concluded that HRH4 may mediate signals in
peripheral tissues and thus have a somewhat different physiology,
particularly in immune regulation and inflammatory processes, from HRH3.
They suggested that different agonists and antagonists will be required
for therapy and biologic analysis.
Liu et al. (2001) cloned Hrh4 cDNAs from rat, mouse, and guinea pig, all
of which encode proteins less than 70% homologous to the human protein.
Most abundant expression was detected in bone marrow and spleen of these
species. The murine receptors had lower affinity for histamine than did
those of humans and guinea pigs, and there was even greater species
differences in binding and functional responses to pharmacologic
ligands. Liu et al. (2001) concluded that in vivo studies will be
difficult to interpret in the absence of selective and comparable HRH4
reagents.
GENE STRUCTURE
By genomic sequence analysis, Oda et al. (2000) determined that the HRH4
gene contains 3 exons.
Coge et al. (2001) found that the single-copy HRH4 gene spans more than
21 kb with the exons separated by 2 large (more than 7.0 kb) introns. It
encodes no apparent splice variants. The HRH4 promoter lacks TATA and
CAAT boxes and GC-rich regions, but contains multiple regulatory
elements, including sites for GATA1 (305371) and CEBPB (189965). There
is also a uteroglobin (UGB; 192020) promoter-binding factor, which is
known to mediate antiinflammatory responses in the lung.
MAPPING
By genomic sequence analysis, Oda et al. (2000) mapped the HRH4 gene to
chromosome 18q11.2. Coge et al. (2001) confirmed this localization by
radiation hybrid analysis.
*FIELD* RF
1. Coge, F.; Guenin, S.-P.; Rique, H.; Boutin, J. A.; Galizzi, J.-P.
: Structure and expression of the human histamine H(4)-receptor gene. Biochem.
Biophys. Res. Commun. 284: 301-309, 2001.
2. Liu, C.; Ma, X.-J.; Jiang, X.; Wilson, S. J.; Hofstra, C. L.; Blevitt,
J.; Pyati, J.; Li, X.; Chai, W.; Carruthers, N.; Lovenberg, T. W.
: Cloning and pharmacological characterization of a fourth histamine
receptor (H(4)) expressed in bone marrow. Molec. Pharm. 59: 420-426,
2001.
3. Liu, C.; Wilson, S. J.; Kuei, C.; Lovenberg, T. W.: Comparison
of human, mouse, rat, and guinea pig histamine H(4) receptors reveals
substantial pharmacological species variation. J. Pharm. Exp. Ther. 299:
121-130, 2001.
4. Morse, K. L.; Behan, J.; Laz, T. M.; West, R. E., Jr.; Greenfeder,
S. A.; Anthes, J. C.; Umland, S.; Wan, Y.; Hipkin, R. W.; Gonsiorek,
W.; Shin, N.; Gustafson, E. L.; Qiao, X.; Wang, S.; Hedrick, J. A.;
Greene, J.; Bayne, M.; Monsma, F. J., Jr.: Cloning and characterization
of a novel human histamine receptor. J. Pharm. Exp. Ther. 296: 1058-1066,
2001.
5. Nakamura, T.; Itadani, H.; Hidaka, Y.; Ohta, M.; Tanaka, K.: Molecular
cloning and characterization of a new human histamine receptor, HH4R. Biochem.
Biophys. Res. Commun. 279: 615-620, 2000.
6. Nguyen, T.; Shapiro, D. A.; George, S. R.; Setola, V.; Lee, D.
K.; Cheng, R.; Rauser, L.; Lee, S. P.; Lynch, K. R.; Roth, B. L.;
O'Dowd, B. F.: Discovery of a novel member of the histamine receptor
family. Molec. Pharm. 59: 427-433, 2001.
7. Oda, T.; Morikawa, N.; Saito, Y.; Masuho, Y.; Matsumoto, S.: Molecular
cloning and characterization of a novel type of histamine receptor
preferentially expressed in leukocytes. J. Biol. Chem. 275: 36781-36786,
2000.
8. Zhu, Y.; Michalovich, D.; Wu, H.-L.; Tan, K. B.; Dytko, G. M.;
Mannan, I. J.; Boyce, R.; Alston, J.; Tierney, L. A.; Li, X.; Herrity,
N. C.; Vawter, L.; Sarau, H. M.; Ames, R. S.; Davenport, C. M.; Hieble,
J. P.; Wilson, S.; Bergsma, D. J.; Fitzgerald, L. R.: Cloning, expression,
and pharmacological characterization of a novel histamine receptor. Molec.
Pharm. 59: 434-441, 2001.
*FIELD* CD
Paul J. Converse: 3/26/2002
*FIELD* ED
alopez: 12/16/2005
terry: 1/2/2003
mgross: 3/26/2002