Full text data of LAMTOR4
LAMTOR4
(C7orf59)
[Confidence: low (only semi-automatic identification from reviews)]
Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; Ragulator complex protein LAMTOR4, N-terminally processed)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; Ragulator complex protein LAMTOR4, N-terminally processed)
Note: presumably soluble (membrane word is not in UniProt keywords or features)
UniProt
Q0VGL1
ID LTOR4_HUMAN Reviewed; 99 AA.
AC Q0VGL1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-SEP-2006, sequence version 1.
DT 22-JAN-2014, entry version 60.
DE RecName: Full=Ragulator complex protein LAMTOR4;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
DE Contains:
DE RecName: Full=Ragulator complex protein LAMTOR4, N-terminally processed;
GN Name=LAMTOR4; Synonyms=C7orf59;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP FUNCTION IN MTORC1 SIGNALING, IDENTIFICATION IN RAGULATOR COMPLEX,
RP INTERACTION WITH MTORC1 COMPLEX AND RAG GTPASES, AND SUBCELLULAR
RP LOCATION.
RX PubMed=22980980; DOI=10.1016/j.cell.2012.07.032;
RA Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M.;
RT "Ragulator is a GEF for the Rag GTPases that signal amino acid levels
RT to mTORC1.";
RL Cell 150:1196-1208(2012).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, AND MASS
RP SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: As part of the Ragulator complex it is involved in amino
CC acid sensing and activation of mTORC1, a signaling complex
CC promoting cell growth in response to growth factors, energy
CC levels, and amino acids. Activated by amino acids through a
CC mechanism involving the lysosomal V-ATPase, the Ragulator
CC functions as a guanine nucleotide exchange factor activating the
CC small GTPases Rag. Activated Ragulator and Rag GTPases function as
CC a scaffold recruiting mTORC1 to lysosomes where it is in turn
CC activated.
CC -!- SUBUNIT: Part of the Ragulator complex composed of LAMTOR1,
CC LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a
CC heterodimer that interacts, through LAMTOR1, with a LAMTOR2,
CC LAMTOR3 heterodimer. The Ragulator complex interacts with both the
CC mTORC1 complex and heterodimers constituted of the Rag GTPases
CC RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid
CC availability.
CC -!- SUBCELLULAR LOCATION: Lysosome.
CC -!- SIMILARITY: Belongs to the LAMTOR4 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CH471091; EAW76585.1; -; Genomic_DNA.
DR EMBL; BC063401; AAH63401.1; -; mRNA.
DR EMBL; BC105609; AAI05610.1; -; mRNA.
DR EMBL; BC130553; AAI30554.1; -; mRNA.
DR EMBL; BC130559; AAI30560.1; -; mRNA.
DR RefSeq; NP_001008396.1; NM_001008395.2.
DR UniGene; Hs.406520; -.
DR ProteinModelPortal; Q0VGL1; -.
DR IntAct; Q0VGL1; 8.
DR STRING; 9606.ENSP00000343118; -.
DR DMDM; 121940512; -.
DR PaxDb; Q0VGL1; -.
DR PRIDE; Q0VGL1; -.
DR DNASU; 389541; -.
DR Ensembl; ENST00000341942; ENSP00000343118; ENSG00000188186.
DR GeneID; 389541; -.
DR KEGG; hsa:389541; -.
DR UCSC; uc003utq.2; human.
DR CTD; 389541; -.
DR GeneCards; GC07P099747; -.
DR H-InvDB; HIX0033651; -.
DR HGNC; HGNC:33772; LAMTOR4.
DR HPA; HPA020998; -.
DR neXtProt; NX_Q0VGL1; -.
DR PharmGKB; PA162380687; -.
DR eggNOG; NOG70902; -.
DR HOGENOM; HOG000047533; -.
DR HOVERGEN; HBG107668; -.
DR InParanoid; Q0VGL1; -.
DR OMA; RTACRFR; -.
DR OrthoDB; EOG738071; -.
DR PhylomeDB; Q0VGL1; -.
DR ChiTaRS; C7orf59; human.
DR GenomeRNAi; 389541; -.
DR NextBio; 102926; -.
DR ArrayExpress; Q0VGL1; -.
DR Bgee; Q0VGL1; -.
DR CleanEx; HS_C7orf59; -.
DR Genevestigator; Q0VGL1; -.
DR GO; GO:0005764; C:lysosome; IDA:UniProtKB.
DR GO; GO:0071986; C:Ragulator complex; IDA:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
DR GO; GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB.
DR GO; GO:0061462; P:protein localization to lysosome; IMP:UniProtKB.
DR GO; GO:0008361; P:regulation of cell size; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Lysosome; Reference proteome.
FT CHAIN 1 99 Ragulator complex protein LAMTOR4.
FT /FTId=PRO_0000424498.
FT INIT_MET 1 1 Removed; alternate.
FT CHAIN 2 99 Ragulator complex protein LAMTOR4, N-
FT terminally processed.
FT /FTId=PRO_0000325841.
FT MOD_RES 1 1 N-acetylmethionine.
FT MOD_RES 2 2 N-acetylthreonine; in Ragulator complex
FT protein LAMTOR4, N-terminally processed.
SQ SEQUENCE 99 AA; 10741 MW; 0FB3D6613F295DEB CRC64;
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHRGMN
VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
//
ID LTOR4_HUMAN Reviewed; 99 AA.
AC Q0VGL1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-SEP-2006, sequence version 1.
DT 22-JAN-2014, entry version 60.
DE RecName: Full=Ragulator complex protein LAMTOR4;
DE AltName: Full=Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4;
DE Contains:
DE RecName: Full=Ragulator complex protein LAMTOR4, N-terminally processed;
GN Name=LAMTOR4; Synonyms=C7orf59;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, MASS SPECTROMETRY, AND
RP CLEAVAGE OF INITIATOR METHIONINE.
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
RA Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in
RT a refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP FUNCTION IN MTORC1 SIGNALING, IDENTIFICATION IN RAGULATOR COMPLEX,
RP INTERACTION WITH MTORC1 COMPLEX AND RAG GTPASES, AND SUBCELLULAR
RP LOCATION.
RX PubMed=22980980; DOI=10.1016/j.cell.2012.07.032;
RA Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M.;
RT "Ragulator is a GEF for the Rag GTPases that signal amino acid levels
RT to mTORC1.";
RL Cell 150:1196-1208(2012).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2, AND MASS
RP SPECTROMETRY.
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
RA Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
RA Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-
RT terminal acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: As part of the Ragulator complex it is involved in amino
CC acid sensing and activation of mTORC1, a signaling complex
CC promoting cell growth in response to growth factors, energy
CC levels, and amino acids. Activated by amino acids through a
CC mechanism involving the lysosomal V-ATPase, the Ragulator
CC functions as a guanine nucleotide exchange factor activating the
CC small GTPases Rag. Activated Ragulator and Rag GTPases function as
CC a scaffold recruiting mTORC1 to lysosomes where it is in turn
CC activated.
CC -!- SUBUNIT: Part of the Ragulator complex composed of LAMTOR1,
CC LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a
CC heterodimer that interacts, through LAMTOR1, with a LAMTOR2,
CC LAMTOR3 heterodimer. The Ragulator complex interacts with both the
CC mTORC1 complex and heterodimers constituted of the Rag GTPases
CC RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid
CC availability.
CC -!- SUBCELLULAR LOCATION: Lysosome.
CC -!- SIMILARITY: Belongs to the LAMTOR4 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; CH471091; EAW76585.1; -; Genomic_DNA.
DR EMBL; BC063401; AAH63401.1; -; mRNA.
DR EMBL; BC105609; AAI05610.1; -; mRNA.
DR EMBL; BC130553; AAI30554.1; -; mRNA.
DR EMBL; BC130559; AAI30560.1; -; mRNA.
DR RefSeq; NP_001008396.1; NM_001008395.2.
DR UniGene; Hs.406520; -.
DR ProteinModelPortal; Q0VGL1; -.
DR IntAct; Q0VGL1; 8.
DR STRING; 9606.ENSP00000343118; -.
DR DMDM; 121940512; -.
DR PaxDb; Q0VGL1; -.
DR PRIDE; Q0VGL1; -.
DR DNASU; 389541; -.
DR Ensembl; ENST00000341942; ENSP00000343118; ENSG00000188186.
DR GeneID; 389541; -.
DR KEGG; hsa:389541; -.
DR UCSC; uc003utq.2; human.
DR CTD; 389541; -.
DR GeneCards; GC07P099747; -.
DR H-InvDB; HIX0033651; -.
DR HGNC; HGNC:33772; LAMTOR4.
DR HPA; HPA020998; -.
DR neXtProt; NX_Q0VGL1; -.
DR PharmGKB; PA162380687; -.
DR eggNOG; NOG70902; -.
DR HOGENOM; HOG000047533; -.
DR HOVERGEN; HBG107668; -.
DR InParanoid; Q0VGL1; -.
DR OMA; RTACRFR; -.
DR OrthoDB; EOG738071; -.
DR PhylomeDB; Q0VGL1; -.
DR ChiTaRS; C7orf59; human.
DR GenomeRNAi; 389541; -.
DR NextBio; 102926; -.
DR ArrayExpress; Q0VGL1; -.
DR Bgee; Q0VGL1; -.
DR CleanEx; HS_C7orf59; -.
DR Genevestigator; Q0VGL1; -.
DR GO; GO:0005764; C:lysosome; IDA:UniProtKB.
DR GO; GO:0071986; C:Ragulator complex; IDA:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IMP:UniProtKB.
DR GO; GO:0032008; P:positive regulation of TOR signaling cascade; IMP:UniProtKB.
DR GO; GO:0061462; P:protein localization to lysosome; IMP:UniProtKB.
DR GO; GO:0008361; P:regulation of cell size; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Acetylation; Complete proteome; Lysosome; Reference proteome.
FT CHAIN 1 99 Ragulator complex protein LAMTOR4.
FT /FTId=PRO_0000424498.
FT INIT_MET 1 1 Removed; alternate.
FT CHAIN 2 99 Ragulator complex protein LAMTOR4, N-
FT terminally processed.
FT /FTId=PRO_0000325841.
FT MOD_RES 1 1 N-acetylmethionine.
FT MOD_RES 2 2 N-acetylthreonine; in Ragulator complex
FT protein LAMTOR4, N-terminally processed.
SQ SEQUENCE 99 AA; 10741 MW; 0FB3D6613F295DEB CRC64;
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA CGFRLHRGMN
VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
//