LTOR4_HUMAN

Source: PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: LAMTOR4 , C7orf59
Protein names and data: LTOR4_HUMAN , Ragulator complex protein LAMTOR4 , Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4; Ragulator complex protein LAMTOR4, N-terminally processed Lenght: 99 a.a.
Mass: 10741 Da
fasta formatted sequence
Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.
Cellular location: Lysosome.

Database cross-references

UniProt: Q0VGL1
Ensembl: ENST00000341942
neXtProt: NX_Q0VGL1
Antibodypedia: Q0VGL1 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.