Full text data of TMEM205
TMEM205
[Confidence: medium (present in either hRBCD or BSc_CH or PM22954596)]
Transmembrane protein 205
Transmembrane protein 205
UniProt
Q6UW68
ID TM205_HUMAN Reviewed; 189 AA.
AC Q6UW68;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-JUL-2004, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Transmembrane protein 205;
GN Name=TMEM205; ORFNames=UNQ501/PRO1018;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20589834; DOI=10.1002/jcp.22287;
RA Shen D.W., Ma J., Okabe M., Zhang G., Xia D., Gottesman M.M.;
RT "Elevated expression of TMEM205, a hypothetical membrane protein, is
RT associated with cisplatin resistance.";
RL J. Cell. Physiol. 225:822-828(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: In cancer cells, plays a role in resistance to the
CC chemotherapeutic agent cisplatin.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC Note=Located on cell surface microvilli. In cancer cells,
CC transition in subcellular location from cell surface to
CC intracellular regions correlates the progression of cisplatin
CC resistance.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in
CC pancreas, followed by adrenal gland, thyroid, liver, mammary
CC gland, prostate, kidney, and retina; lowest levels in skeletal
CC muscle. Overexpressed in cisplatin-resistant cancer cells (at
CC protein level).
CC -!- SIMILARITY: Belongs to the TMEM205 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358949; AAQ89308.1; -; mRNA.
DR EMBL; AK291979; BAF84668.1; -; mRNA.
DR EMBL; CH471106; EAW84191.1; -; Genomic_DNA.
DR EMBL; BC064948; AAH64948.1; -; mRNA.
DR EMBL; BC091472; AAH91472.1; -; mRNA.
DR RefSeq; NP_001138888.1; NM_001145416.1.
DR RefSeq; NP_212133.1; NM_033408.3.
DR RefSeq; NP_940938.1; NM_198536.2.
DR RefSeq; XP_005259955.1; XM_005259898.1.
DR RefSeq; XP_005259956.1; XM_005259899.1.
DR RefSeq; XP_005259957.1; XM_005259900.1.
DR RefSeq; XP_005259958.1; XM_005259901.1.
DR RefSeq; XP_005259959.1; XM_005259902.1.
DR UniGene; Hs.8036; -.
DR ProteinModelPortal; Q6UW68; -.
DR IntAct; Q6UW68; 1.
DR STRING; 9606.ENSP00000222124; -.
DR TCDB; 9.A.55.1.1; the tmem205 (tmem205) family.
DR PhosphoSite; Q6UW68; -.
DR DMDM; 74749383; -.
DR PaxDb; Q6UW68; -.
DR PeptideAtlas; Q6UW68; -.
DR PRIDE; Q6UW68; -.
DR DNASU; 374882; -.
DR Ensembl; ENST00000354882; ENSP00000346954; ENSG00000105518.
DR Ensembl; ENST00000447337; ENSP00000398258; ENSG00000105518.
DR Ensembl; ENST00000586590; ENSP00000466986; ENSG00000105518.
DR Ensembl; ENST00000586956; ENSP00000465483; ENSG00000105518.
DR Ensembl; ENST00000587948; ENSP00000465149; ENSG00000105518.
DR Ensembl; ENST00000588560; ENSP00000466495; ENSG00000105518.
DR Ensembl; ENST00000589555; ENSP00000465553; ENSG00000105518.
DR Ensembl; ENST00000593256; ENSP00000468733; ENSG00000105518.
DR GeneID; 374882; -.
DR KEGG; hsa:374882; -.
DR UCSC; uc002mqz.2; human.
DR CTD; 374882; -.
DR GeneCards; GC19M011453; -.
DR HGNC; HGNC:29631; TMEM205.
DR HPA; HPA041504; -.
DR MIM; 613771; gene.
DR neXtProt; NX_Q6UW68; -.
DR PharmGKB; PA162406385; -.
DR eggNOG; NOG269385; -.
DR HOGENOM; HOG000160735; -.
DR HOVERGEN; HBG107300; -.
DR InParanoid; Q6UW68; -.
DR OMA; TINARWL; -.
DR PhylomeDB; Q6UW68; -.
DR GenomeRNAi; 374882; -.
DR NextBio; 100311; -.
DR PRO; PR:Q6UW68; -.
DR ArrayExpress; Q6UW68; -.
DR Bgee; Q6UW68; -.
DR CleanEx; HS_TMEM205; -.
DR Genevestigator; Q6UW68; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR025423; DUF4149.
DR Pfam; PF13664; DUF4149; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 189 Transmembrane protein 205.
FT /FTId=PRO_0000317501.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TRANSMEM 81 101 Helical; (Potential).
FT TRANSMEM 166 186 Helical; (Potential).
SQ SEQUENCE 189 AA; 21198 MW; FCC1C48C5B1601B5 CRC64;
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ SKLFPFYFHI
SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT VNARWLEPRT TAAMWALQTV
EKERGLGGEV PGSHQGPDPY RQLREKDPKY SALRQNFFRY HGLSSLCNLG CVLSNGLCLA
GLALEIRSL
//
ID TM205_HUMAN Reviewed; 189 AA.
AC Q6UW68;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
read moreDT 05-JUL-2004, sequence version 1.
DT 22-JAN-2014, entry version 75.
DE RecName: Full=Transmembrane protein 205;
GN Name=TMEM205; ORFNames=UNQ501/PRO1018;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
RA Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale
RT effort to identify novel human secreted and transmembrane proteins: a
RT bioinformatics assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=20589834; DOI=10.1002/jcp.22287;
RA Shen D.W., Ma J., Okabe M., Zhang G., Xia D., Gottesman M.M.;
RT "Elevated expression of TMEM205, a hypothetical membrane protein, is
RT associated with cisplatin resistance.";
RL J. Cell. Physiol. 225:822-828(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: In cancer cells, plays a role in resistance to the
CC chemotherapeutic agent cisplatin.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC Note=Located on cell surface microvilli. In cancer cells,
CC transition in subcellular location from cell surface to
CC intracellular regions correlates the progression of cisplatin
CC resistance.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in
CC pancreas, followed by adrenal gland, thyroid, liver, mammary
CC gland, prostate, kidney, and retina; lowest levels in skeletal
CC muscle. Overexpressed in cisplatin-resistant cancer cells (at
CC protein level).
CC -!- SIMILARITY: Belongs to the TMEM205 family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AY358949; AAQ89308.1; -; mRNA.
DR EMBL; AK291979; BAF84668.1; -; mRNA.
DR EMBL; CH471106; EAW84191.1; -; Genomic_DNA.
DR EMBL; BC064948; AAH64948.1; -; mRNA.
DR EMBL; BC091472; AAH91472.1; -; mRNA.
DR RefSeq; NP_001138888.1; NM_001145416.1.
DR RefSeq; NP_212133.1; NM_033408.3.
DR RefSeq; NP_940938.1; NM_198536.2.
DR RefSeq; XP_005259955.1; XM_005259898.1.
DR RefSeq; XP_005259956.1; XM_005259899.1.
DR RefSeq; XP_005259957.1; XM_005259900.1.
DR RefSeq; XP_005259958.1; XM_005259901.1.
DR RefSeq; XP_005259959.1; XM_005259902.1.
DR UniGene; Hs.8036; -.
DR ProteinModelPortal; Q6UW68; -.
DR IntAct; Q6UW68; 1.
DR STRING; 9606.ENSP00000222124; -.
DR TCDB; 9.A.55.1.1; the tmem205 (tmem205) family.
DR PhosphoSite; Q6UW68; -.
DR DMDM; 74749383; -.
DR PaxDb; Q6UW68; -.
DR PeptideAtlas; Q6UW68; -.
DR PRIDE; Q6UW68; -.
DR DNASU; 374882; -.
DR Ensembl; ENST00000354882; ENSP00000346954; ENSG00000105518.
DR Ensembl; ENST00000447337; ENSP00000398258; ENSG00000105518.
DR Ensembl; ENST00000586590; ENSP00000466986; ENSG00000105518.
DR Ensembl; ENST00000586956; ENSP00000465483; ENSG00000105518.
DR Ensembl; ENST00000587948; ENSP00000465149; ENSG00000105518.
DR Ensembl; ENST00000588560; ENSP00000466495; ENSG00000105518.
DR Ensembl; ENST00000589555; ENSP00000465553; ENSG00000105518.
DR Ensembl; ENST00000593256; ENSP00000468733; ENSG00000105518.
DR GeneID; 374882; -.
DR KEGG; hsa:374882; -.
DR UCSC; uc002mqz.2; human.
DR CTD; 374882; -.
DR GeneCards; GC19M011453; -.
DR HGNC; HGNC:29631; TMEM205.
DR HPA; HPA041504; -.
DR MIM; 613771; gene.
DR neXtProt; NX_Q6UW68; -.
DR PharmGKB; PA162406385; -.
DR eggNOG; NOG269385; -.
DR HOGENOM; HOG000160735; -.
DR HOVERGEN; HBG107300; -.
DR InParanoid; Q6UW68; -.
DR OMA; TINARWL; -.
DR PhylomeDB; Q6UW68; -.
DR GenomeRNAi; 374882; -.
DR NextBio; 100311; -.
DR PRO; PR:Q6UW68; -.
DR ArrayExpress; Q6UW68; -.
DR Bgee; Q6UW68; -.
DR CleanEx; HS_TMEM205; -.
DR Genevestigator; Q6UW68; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR InterPro; IPR025423; DUF4149.
DR Pfam; PF13664; DUF4149; 1.
PE 1: Evidence at protein level;
KW Complete proteome; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1 189 Transmembrane protein 205.
FT /FTId=PRO_0000317501.
FT TRANSMEM 18 38 Helical; (Potential).
FT TRANSMEM 53 73 Helical; (Potential).
FT TRANSMEM 81 101 Helical; (Potential).
FT TRANSMEM 166 186 Helical; (Potential).
SQ SEQUENCE 189 AA; 21198 MW; FCC1C48C5B1601B5 CRC64;
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ SKLFPFYFHI
SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT VNARWLEPRT TAAMWALQTV
EKERGLGGEV PGSHQGPDPY RQLREKDPKY SALRQNFFRY HGLSSLCNLG CVLSNGLCLA
GLALEIRSL
//
MIM
613771
*RECORD*
*FIELD* NO
613771
*FIELD* TI
*613771 TRANSMEMBRANE PROTEIN 205; TMEM205
*FIELD* TX
CLONING
By screening for genes upregulated in cisplatin-resistant human cancer
read morecell lines compared with parental cell lines, Shen et al. (2010) cloned
TMEM205. The deduced 189-amino acid protein has 4 transmembrane domains.
Quantitative real-time PCR detected variable TMEM205 expression in all
29 human tissues examined, with highest expression in pancreas, followed
by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and
retina. Lowest expression was detected in skeletal muscle. Western blot
analysis detected TMEM205 at an apparent molecular mass of about 21 kD
in membrane fractions of early cisplatin-resistant cells. Immunoelectron
microscopy showed that TMEM205 localized to cell surface microvilli.
GENE FUNCTION
Using RT-PCR and immunoblot analyses, Shen et al. (2010) confirmed that
expression of TMEM205 was upregulated in cisplatin-resistant human and
mouse cells compared with parental cell lines. Transfection of TMEM205
into naive cells induced cisplatin resistance. Development of cisplatin
resistance was associated with reduced intracellular cisplatin levels
and redistribution of TMEM205 from the cell surface to the trans-Golgi
region. Shen et al. (2010) hypothesized that TMEM205 may be a cisplatin
transporter that permits drug resistance by reducing the intracellular
cisplatin concentration.
MAPPING
Hartz (2011) mapped the TMEM205 gene to chromosome 19p13.2 based on an
alignment of the TMEM205 sequence (GenBank GENBANK AY358949) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 2/23/2011.
2. Shen, D.-W.; Ma, J.; Okabe, M.; Zhang, G.; Xia, D.; Gottesman,
M. M.: Elevated expression of TMEM205, a hypothetical membrane protein,
is associated with cisplatin resistance. J. Cell. Physiol. 225:
822-828, 2010.
*FIELD* CD
Patricia A. Hartz: 2/24/2011
*FIELD* ED
mgross: 02/24/2011
mgross: 2/24/2011
*RECORD*
*FIELD* NO
613771
*FIELD* TI
*613771 TRANSMEMBRANE PROTEIN 205; TMEM205
*FIELD* TX
CLONING
By screening for genes upregulated in cisplatin-resistant human cancer
read morecell lines compared with parental cell lines, Shen et al. (2010) cloned
TMEM205. The deduced 189-amino acid protein has 4 transmembrane domains.
Quantitative real-time PCR detected variable TMEM205 expression in all
29 human tissues examined, with highest expression in pancreas, followed
by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and
retina. Lowest expression was detected in skeletal muscle. Western blot
analysis detected TMEM205 at an apparent molecular mass of about 21 kD
in membrane fractions of early cisplatin-resistant cells. Immunoelectron
microscopy showed that TMEM205 localized to cell surface microvilli.
GENE FUNCTION
Using RT-PCR and immunoblot analyses, Shen et al. (2010) confirmed that
expression of TMEM205 was upregulated in cisplatin-resistant human and
mouse cells compared with parental cell lines. Transfection of TMEM205
into naive cells induced cisplatin resistance. Development of cisplatin
resistance was associated with reduced intracellular cisplatin levels
and redistribution of TMEM205 from the cell surface to the trans-Golgi
region. Shen et al. (2010) hypothesized that TMEM205 may be a cisplatin
transporter that permits drug resistance by reducing the intracellular
cisplatin concentration.
MAPPING
Hartz (2011) mapped the TMEM205 gene to chromosome 19p13.2 based on an
alignment of the TMEM205 sequence (GenBank GENBANK AY358949) with the
genomic sequence (GRCh37).
*FIELD* RF
1. Hartz, P. A.: Personal Communication. Baltimore, Md. 2/23/2011.
2. Shen, D.-W.; Ma, J.; Okabe, M.; Zhang, G.; Xia, D.; Gottesman,
M. M.: Elevated expression of TMEM205, a hypothetical membrane protein,
is associated with cisplatin resistance. J. Cell. Physiol. 225:
822-828, 2010.
*FIELD* CD
Patricia A. Hartz: 2/24/2011
*FIELD* ED
mgross: 02/24/2011
mgross: 2/24/2011