Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: TMEM205 , UNQ501/PRO1018
Protein names and data: TM205_HUMAN , Transmembrane protein 205 Lenght: 189 a.a.
Mass: 21198 Da
fasta formatted sequence

Function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
Cellular location: Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

Database cross-references

UniProt: Q6UW68
Ensembl: ENST00000354882
Ensembl: ENST00000447337
Ensembl: ENST00000586590
Ensembl: ENST00000586956
Ensembl: ENST00000587948
Ensembl: ENST00000588560
Ensembl: ENST00000589555
Ensembl: ENST00000593256
MIM: 613771
neXtProt: NX_Q6UW68
Antibodypedia: Q6UW68 (may not find the protein thus also not any antibody)
Local full text data: click here

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