Source: PM19886704
Marked as 'Membrane associated protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: ABCE1 , RLI, RNASEL1, RNASELI, RNS4I , OK/SW-cl.40
Protein names and data: ABCE1_HUMAN , ATP-binding cassette sub-family E member 1 , 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I Lenght: 599 a.a.
Mass: 67314 Da
fasta formatted sequence

Function: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Cellular location: Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.

Genetic variants

Database cross-references

UniProt: P61221
Ensembl: ENST00000296577
MIM: 601213
neXtProt: NX_P61221
Antibodypedia: P61221 (may not find the protein thus also not any antibody)
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