CARD8_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CARD8 , KIAA0955, NDPP1
Protein names and data: CARD8_HUMAN , Caspase recruitment domain-containing protein 8 , Apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; Tumor up-regulated CARD-containing antagonist of CASP9; TUCAN Lenght: 431 a.a.
Mass: 48933 Da
fasta formatted sequence
Function: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
Cellular location: Cytoplasm. Nucleus.
Tissue specificity: High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Genetic variants

Database cross-references

UniProt: Q9Y2G2
Ensembl: ENST00000359009
Ensembl: ENST00000391898
Ensembl: ENST00000447740
Ensembl: ENST00000519940
Ensembl: ENST00000520015
Ensembl: ENST00000520153
Ensembl: ENST00000520753
Ensembl: ENST00000521613
MIM: 609051
neXtProt: NX_Q9Y2G2
Antibodypedia: Q9Y2G2 (may not find the protein thus also not any antibody)
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