CD8B_HUMAN

Source: PM19886704
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: CD8B , CD8B1
Protein names and data: CD8B_HUMAN , T-cell surface glycoprotein CD8 beta chain , CD8b; Flags: Precursor Lenght: 210 a.a.
Mass: 23722 Da
fasta formatted sequence
Function: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 3: Secreted (Probable). Isoform 4: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 5: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 6: Secreted (Probable). Isoform 7: Secreted (Probable). Isoform 8: Secreted (Probable).
Tissue specificity: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

Database cross-references

UniProt: P10966
Ensembl: ENST00000331469
Ensembl: ENST00000349455
Ensembl: ENST00000390655
Ensembl: ENST00000393759
Ensembl: ENST00000393761
MIM: 186730
neXtProt: NX_P10966
Antibodypedia: P10966 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.