DHB11_HUMAN

Source: PM23856902
PM22954596
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: HSD17B11 , DHRS8, PAN1B , PSEC0029, UNQ207/PRO233
Protein names and data: DHB11_HUMAN , Estradiol 17-beta-dehydrogenase 11; 1.1.1.62 , 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Flags: Precursor Lenght: 300 a.a.
Mass: 32936 Da
fasta formatted sequence
Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.
Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Cellular location: Secreted (Potential).
Tissue specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.

Database cross-references

UniProt: Q8NBQ5
Ensembl: ENST00000358290
MIM: 612831
neXtProt: NX_Q8NBQ5
Antibodypedia: Q8NBQ5 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.