EIF3J_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF3J , EIF3S1 , PRO0391
Protein names and data: EIF3J_HUMAN , Eukaryotic translation initiation factor 3 subunit J; eIF3j , Eukaryotic translation initiation factor 3 subunit 1; eIF-3-alpha; eIF3 p35 Lenght: 258 a.a.
Mass: 29062 Da
fasta formatted sequence
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.
Cellular location: Cytoplasm (By similarity).

Genetic variants

Database cross-references

UniProt: O75822
Ensembl: ENST00000261868
MIM: 603910
neXtProt: NX_O75822
Antibodypedia: O75822 (may not find the protein thus also not any antibody)
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