EIF3M_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: EIF3M , HFLB5, PCID1 , GA17, PNAS-125
Protein names and data: EIF3M_HUMAN , Eukaryotic translation initiation factor 3 subunit M; eIF3m , Fetal lung protein B5; hFL-B5; PCI domain-containing protein 1 Lenght: 374 a.a.
Mass: 42503 Da
fasta formatted sequence
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).
Cellular location: Cytoplasm (By similarity).
Tissue specificity: Broadly expressed.

Genetic variants

Database cross-references

UniProt: Q7L2H7
Ensembl: ENST00000531120
MIM: 609641
neXtProt: NX_Q7L2H7
Antibodypedia: Q7L2H7 (may not find the protein thus also not any antibody)
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