RBCC Red Blood Cell Collection

FCG2A_HUMAN

Source: PM19886704
Marked as 'Integral membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: FCGR2A , CD32, FCG2, FCGR2A1, IGFR2
Protein names and data: FCG2A_HUMAN , Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a , CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; CD32; Flags: Precursor Lenght: 317 a.a.
Mass: 35001 Da
fasta formatted sequence
Function: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Cellular location: Cell membrane; Single-pass type I membrane protein.
Tissue specificity: Found on monocytes, neutrophils and eosinophil platelets.

Genetic variants

63 - 63 Q -> R (in dbSNP:rs9427398). VAR_054857 9427398
140 - 140 M -> V (in dbSNP:rs4986941). VAR_054858 4986941
167 - 167 H -> R (may be associated with susceptibility to lupus nephritis; does not efficiently recognize IgG2; dbSNP:rs1801274). VAR_003955 1801274
218 - 218 I -> V (in dbSNP:rs17851834). VAR_054859 17851834

Database cross-references

UniProt: P12318
Ensembl: ENST00000271450
Ensembl: ENST00000367972
MIM: 146790
neXtProt: NX_P12318
Antibodypedia: P12318 (may not find the protein thus also not any antibody)
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