MY18A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: MYO18A , KIAA0216, MYSPDZ
Protein names and data: MY18A_HUMAN , Unconventional myosin-XVIIIa , Molecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain Lenght: 2054 a.a.
Mass: 233115 Da
fasta formatted sequence
Function: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.
Cellular location: Isoform 1: Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Cytoplasm, cytoskeleton. Note=Colocalizes with actin. Isoform 2: Cytoplasm. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm. Golgi apparatus. Golgi apparatus, trans- Golgi network. Note=Recruited to the Golgi apparatus by GOLPH3.

Genetic variants

Database cross-references

UniProt: Q92614
Ensembl: ENST00000527372
Ensembl: ENST00000531253
Ensembl: ENST00000533112
MIM: 609517
MIM: 610067
neXtProt: NX_Q92614
Antibodypedia: Q92614 (may not find the protein thus also not any antibody)
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