PLSL_HUMAN

Source: hRBCD ; ID: IPI00010471
PM19886704
PM23856902
PM22954596
Marked as 'Membrane associated protein'
Confidence: high (present in two of the MS resources) Search PubMed for
(RBC AND this entry)
Gene names: LCP1 , PLS2
Protein names and data: PLSL_HUMAN , Plastin-2 , L-plastin; LC64P; Lymphocyte cytosolic protein 1; LCP-1 Lenght: 627 a.a.
Mass: 70288 Da
fasta formatted sequence
Function: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.
Disease:
Cellular location: Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Associated with the actin cytoskeleton at membrane ruffles (By similarity). Relocalizes to actin-rich cell projections upon serine phosphorylation.
Tissue specificity: Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.

Genetic variants

Database cross-references

UniProt: P13796
Ensembl: ENST00000323076
Ensembl: ENST00000398576
MIM: 153430
neXtProt: NX_P13796
Antibodypedia: P13796 (may not find the protein thus also not any antibody)
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