PPAC_HUMAN

Source: hRBCD ; ID: IPI00218847
PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)
Gene names: ACP1
Protein names and data: PPAC_HUMAN , Low molecular weight phosphotyrosine protein phosphatase; LMW-PTP; LMW-PTPase; 3.1.3.48 , Adipocyte acid phosphatase; Low molecular weight cytosolic acid phosphatase; 3.1.3.2; Red cell acid phosphatase 1 Lenght: 158 a.a.
Mass: 18042 Da
fasta formatted sequence
Function: Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. A phosphate monoester + H(2)O = an alcohol + phosphate.
Cellular location: Cytoplasm.
Tissue specificity: T-lymphocytes express only isoform 2.

Genetic variants

ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes, F and S, which are produced in allele-specific ratios. The sequence shown is that of allele ACP1*B and allele ACP1*C.

Database cross-references

UniProt: P24666
Ensembl: ENST00000272065
Ensembl: ENST00000272067
MIM: 171500
neXtProt: NX_P24666
Antibodypedia: P24666 (may not find the protein thus also not any antibody)
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