Source: BSc_CH
Marked as 'Integral membrane protein'
Confidence: medium (present in either hRBCD or BSc_CH or PM22954596) Search PubMed for
(RBC AND this entry)

Gene names: SUN2 , FRIGG, KIAA0668, RAB5IP, UNC84B
Protein names and data: SUN2_HUMAN , SUN domain-containing protein 2 , Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1/unc-84 protein-like 2 Lenght: 717 a.a.
Mass: 80311 Da
fasta formatted sequence

Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.
Cellular location: Nucleus inner membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein (Probable).
Tissue specificity: Widely expressed. Highly expressed in heart, lung and muscle. Weakly expressed in fetal heart. Slightly overexpressed in some heart tissues form patients with congenital heart defects.

Genetic variants

Database cross-references

UniProt: Q9UH99
Ensembl: ENST00000216064
Ensembl: ENST00000405018
Ensembl: ENST00000405510
Ensembl: ENST00000406622
MIM: 613569
neXtProt: NX_Q9UH99
Antibodypedia: Q9UH99 (may not find the protein thus also not any antibody)
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