TFIP8_HUMAN

Source: PM19886704
PM23856902
Marked as 'Non-membrane protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TNFAIP8
Protein names and data: TFIP8_HUMAN , Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8 , Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 Lenght: 198 a.a.
Mass: 23003 Da
fasta formatted sequence
Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Cellular location: Cytoplasm.
Tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.

Genetic variants

Database cross-references

UniProt: O95379
Ensembl: ENST00000274456
Ensembl: ENST00000503646
Ensembl: ENST00000504771
MIM: 612111
neXtProt: NX_O95379
Antibodypedia: O95379 (may not find the protein thus also not any antibody)
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