TS101_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: TSG101
Protein names and data: TS101_HUMAN , Tumor susceptibility gene 101 protein , ESCRT-I complex subunit TSG101 Lenght: 390 a.a.
Mass: 43944 Da
fasta formatted sequence
Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.
Cellular location: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Late endosome membrane; Peripheral membrane protein. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Depending on the stage of the cell cycle, detected in the nucleus. Colocalized with CEP55 in the midbody during cytokinesis.
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Genetic variants

Database cross-references

UniProt: Q99816
Ensembl: ENST00000251968
Ensembl: ENST00000357193
MIM: 601387
neXtProt: NX_Q99816
Antibodypedia: Q99816 (may not find the protein thus also not any antibody)
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