VPS4A_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: VPS4A , VPS4
Protein names and data: VPS4A_HUMAN , Vacuolar protein sorting-associated protein 4A; 3.6.4.6 , Protein SKD2; VPS4-1; hVPS4 Lenght: 437 a.a.
Mass: 48898 Da
fasta formatted sequence
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis.
Catalytic activity: ATP + H(2)O = ADP + phosphate.
Cellular location: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Tissue specificity: Ubiquitously expressed.

Database cross-references

UniProt: Q9UN37
Ensembl: ENST00000254950
MIM: 609982
neXtProt: NX_Q9UN37
Antibodypedia: Q9UN37 (may not find the protein thus also not any antibody)
Local full text data: click here

Users' comments

Login to add a comment.