ZW10_HUMAN

Source: PM19886704
PM23856902
Marked as 'Membrane associated protein'
Confidence: low (only semi-automatic identification from reviews) Search PubMed for
(RBC AND this entry)
Gene names: ZW10
Protein names and data: ZW10_HUMAN , Centromere/kinetochore protein zw10 homolog Lenght: 779 a.a.
Mass: 88829 Da
fasta formatted sequence
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.
Cellular location: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.
Tissue specificity: Widely expressed.

Genetic variants

Database cross-references

UniProt: O43264
Ensembl: ENST00000200135
MIM: 603954
neXtProt: NX_O43264
Antibodypedia: O43264 (may not find the protein thus also not any antibody)
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